FeNO and Cytokines in Respiratory Syncytial Virus (RSV) and Non RSV Bronchiolitis in Relation to Future Asthma

FeNO and Cytokines in RSV and Non RSV Bronchiolitis in Relation to Future Asthma

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02093715

Enrollment

400

Registered

2014-03-21

Start date

2007-07-31

Completion date

Unknown

Last updated

2014-09-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Bronchiolitis

Keywords

Bronchiolitis, FeNO, Asthma, wheezing, RSV

Brief summary

The purpose of this study is to determine Fractional exhaled Nitric-Oxide (FeNO)levels and blood cytokines during acute bronchiolitis, and to seek for correlation between these markers and future development of asthma.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

2 Weeks to 2 Years

Healthy volunteers

Yes

Inclusion criteria

* First episode of shortness of breath * Children in ages 2 weeks to 2 years

Exclusion criteria

* Any chronic disease * Congenital anomalies

Design outcomes

Primary

Measure	Time frame	Description
Physician diagnosed asthma	At the age of 4 years	Modification of The International Study of Asthma and Allergies in Childhood (ISAAC) questionnaires

Secondary

Measure	Time frame	Description
Fractional exhaled Nitric Oxide (FENO) level	During acute bronchiolitis, after 2 and 6 months	FeNO level measured by a rapid-response chemiluminescence analyzer (Eco Physics CLD88 NO analyzer, EcoMedics AG,Switzerland).

Other

Measure	Time frame	Description
Wheezing episode	From recruitment time till the age 4.	—
PCR for respiratory viruses	At recruitment	Polymerase chain reaction (PCR) analysis of nasal secretion for: RSV, Influenza A, Influenza B, Pandemic H1N1, Adenovirus, human metapneumovirus (hMPV), Parainfluenza 1-3, Enterovirus, Bocavirus, Rhinovirus, Corona virus-229E, Corona-OC43, Corona-HKU1 and Corona-NL63.

Countries

Israel

Contacts

Primary ContactYakov Sivan, Professor

sivan@tlvmc.gov.il

Outcome results