Muscle Fatigue Caused by Repetitive Muscle Exercise
Conditions
Brief summary
We hypothesize that adenosine-5'-triphosphate (ATP) supplementation will be able to enhance motor unit recruitment while simultaneously blunting the decline in power and reaction time that is typically seen during repetitive sprints. This will give researchers a better understanding of the mechanism by which ATP supplementation can augment power, especially under high fatiguing conditions.
Detailed description
Healthy participants of similar training status as previously tested will be enrolled into the study. The participants will be randomly assigned to either placebo supplementation or to 400 mg ATP per day for 14 days. The supplements will be taken in the morning and the last dose will be taken 30 min prior to testing on the last day. Testing will be performed at baseline and after the 14 days of supplementation. Ten successive sprints will be conducted on the Wingate apparatus as this has been previously demonstrated to decrease muscle excitability. After the sprints, muscle excitability, reaction time, and vertical jump power will be measured. In addition a blood sample will be obtained before and after supplementation and complete blood hematology and chemistry analyses will be performed. It is expected that ATP supplementation may help maintain muscle excitability and power after the successive sprint sessions.
Interventions
DIETARY_SUPPLEMENTPlacebo
DIETARY_SUPPLEMENTATP
400 mg of ATP
Sponsors
University of Tampa
Metabolic Technologies Inc.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Agree to eating a diet approved by a registered dietician consisting of the following by caloric percentages: 15-20% protein, 44-55% carbohydrate, and 25-30% fat. * Must not have taken performance enhancing supplements for at least 3 months prior to the study start, * Must be a non-smoker. * Must not be taking amino acid supplements. * Must not be using anabolic or catabolic hormones. * Must not be taking any medications known to influence variables to be measured in the study.
Exclusion criteria
* Will not agree to eating a diet approved by a registered dietician consisting of the following by caloric percentages: 15-20% protein, 44-55% carbohydrate, and 25-30% fat. * Has taken performance enhancing supplements for at least 3 months prior to the study start, * Is currently a non-smoker. * Is currently taking amino acid supplements. * Is currently using anabolic or catabolic hormones. * Is currently taking medications known to influence variables to be measured in the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle Excitability | Day 14 | Muscle excitability will be measured using Delsys Wireless Electromyography (EMG) sensors. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Power | Day 14 | Muscle power will be measured using the Wingate and vertical jump power measures. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Reaction Time | Day 14 | Reaction time will be measured using a Dynavision apparatus. |
| Blood Biochemical Analyses | Day 14 | Blood chemistries and hematology will be measured after the 14 days of supplementation. |
Countries
United States
Outcome results
None listed