Effects of Dietary Fibre on Glucose Metabolism and Satiety

Intrinsic Indigestible Carbohydrates as Means to Modulate Colonic Events, With Specific Focus on Metabolism and Satiety

Status

Completed

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02093481

Enrollment

Registered

2014-03-21

Start date

2014-02-28

Completion date

2014-06-30

Last updated

2014-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity, Metabolic Syndrome

Brief summary

The experimental model is a semi-acute study where the purpose of the study is to evaluate food factors related to colonially derived regulation of glucose metabolism (and related parameters) and satiety in healthy subjects.

Interventions

OTHERTest meal

OTHERReference

OTHERPriming

The reference or test meal was eaten 3 days prior to measurements of variables.

OTHERNo priming

The reference or test meal was eaten 1 days prior to measurements of variables.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

PREVENTION

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

20 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* Normal fasting blood glucose, BMI 19-25 kg/m2

Exclusion criteria

* Gastrointestinal diseases or food allergies e.g. lactose-, gluten intolerance, metabolic disorders e.g. diabetes, tobacco/snuff users. Antibiotic or probiotic usage within two weeks, and during study. Vegetarians.

Design outcomes

Primary

Measure	Time frame	Description
Blood glucose	Postprandial 0-180 min after breakfast	The test products are both ingested one day and three days prior to measurements of variables.
Insulin	Postprandial 0-180 min after breakfast	The test products are both ingested one day and three days prior to measurements of variables.
Appetite hormones	Postprandial 0-180 min after breakfast	The test products are both ingested one day and three days prior to measurements of variables.
Markers of colonic fermentation and inflammation	Postprandial 0-180 min after breakfast	The test products are both ingested one day and three days prior to measurements of variables.

Secondary

Measure	Time frame	Description
Subjective satiety	Postprandial 0-180 min after breakfast	The measures of hunger, satiety, and desire to eat with the use of a VAS were determined every hour throughout the postprandial testing sessions.

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 13, 2026