Subfertility
Conditions
Brief summary
Endometrial injury performed in a cycle preceding the one for embryo transfer is associated with an increased implantation and pregnancy rate when carried out during the month preceding that of ovulation induction and fresh embryo transfer. However, there is no evidence about the effect of this intervention on the transfer of cryopreserved embryos.
Interventions
PROCEDUREEndometrial injury
Endometrial biopsy using a pipelle de Cornier
Sponsors
University of Sao Paulo
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Age \> 18 * At least one cryopreserved embryo
Exclusion criteria
* None
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Live birth | 10 months | The complete expulsion or extraction from its mother of a product of fertilization, irrespective of the duration of the pregnancy, which, after such separation, breathes or shows any other evidence of life, such as heart beat, umbilical cord pulsation, or definite movement of voluntary muscles, irrespective of whether the umbilical cord has been cut or the placenta is attached. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical pregnancy | 3 months | A pregnancy diagnosed by ultrasonographic visualization of one or more gestational sacs or definitive clinical signs of pregnancy. It includes ectopic pregnancy. Note: Multiple gestational sacs are counted as one clinical pregnancy. |
| Miscarriage | 5 months | The spontaneous loss of a clinical pregnancy |
Other
| Measure | Time frame | Description |
|---|---|---|
| Multiple pregnancy | 3 months | A pregnancy with more than one gestational sac. |
Countries
Brazil
Outcome results
None listed