Leptin Receptors in the Bariatric Surgical Population Within the University of Pittsburgh Medical System: A Cohort Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02093416

Enrollment

Registered

2014-03-21

Start date

2013-10-31

Completion date

2014-07-31

Last updated

2016-01-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Keywords

Obesity, Leptin

Brief summary

Prospective cohort study evaluating the role of leptin receptors in the bariatric surgical population compared with non obese controls. Additionally serum levels of leptin, ghrelin, motilin and PYY will be compared amongst the different BMI classes and a quality of life questionnaire completed by all participants. The hypothesis is that obese individuals have lower leptin receptors in enterocytes which is partially responsible for the higher serum leptin levels without appropriate control of satiety.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Endoscopic Intervention

Exclusion criteria

* 18 years of age or older * No acute GI bleeding

Design outcomes

Primary

Measure	Time frame	Description
PCR test for Leptin Receptors	1 week	Endoscopic biopsies of enterocytes will be measured via PCR

Secondary

Measure	Time frame	Description
ELISA test for ghrelin, motilin, leptin and PYY	1 week	Blood samples collected to determine hormones via ELISA
IWQOL lite questionnaire	1 week	Quality of Life questionnaire on obesity

Countries

United States

Outcome results