Growth Hormone Deficiency and Empty Sella Cardio-Metabolic Risk Factors in Obesity: a Cross-Sectional Study

Growth Hormone Deficiency, Empty Sella and Cardio-Metabolic Risk Factors in Obesity: a Cross-Sectional Study.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02092779

Enrollment

447

Registered

2014-03-20

Start date

2007-03-31

Completion date

2014-03-31

Last updated

2014-03-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Brief summary

Obesity is a disease not always attributable to nutritional imbalance, frequently associated with changes in key hypothalamic-pituitary (HP) axes. The regain of weight loss after hypochaloric diets has been ascribed to these HP disregulations. The aim of the study is to explore pituitary morphology and its association with pituitary function and metabolic phenotype in outpatient obese individuals evaluated in the period 2010-2013 at the Department of Experimental Medicine of the University of Rome La Sapienza, with features of HP disease in a cross-sectional .

Interventions

None listed

Study design

Observational model

CASE_CROSSOVER

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Adult obese

Exclusion criteria

* psychiatric disturbances, pregnancy, lactation, or drugs known to affect pituitary function

Design outcomes

Primary

Measure	Time frame
Cranio-caudal pituitary diameter in millimeters	Participants will be followed for the duration of day hospital stay, an expected average of 1 week

Secondary

Measure	Time frame
Growth hormone releasing hormone plus arginine test for GH secretion μg/L	Participants will be followed for the duration of day hospital stay, an expected average of 1 week

Outcome results