Effects of Cholecalciferol Supplementation on Bone Health and Muscle Strength in Adults During Post-burn Period

Effects of a One Year Cholecalciferol Supplementation on Bone Health and Muscle Strength in Adults During Post-burn Period

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02092701

Enrollment

Unknown

Registered

2014-03-20

Start date

2012-10-31

Completion date

2013-10-31

Last updated

2014-03-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Burn Injury, Vitamin D

Brief summary

Vitamin D has pleiotropic effects. Burn patients are at risk of hypovitaminosis D and may experience post-injury osteopenia and sarcopenia. Investigators hypothesized that vitamin D supplementation during one year can improve bone and muscle health in post-burn period.

Interventions

DRUGCholecalciferol

Study design

Allocation

RANDOMIZED

Primary purpose

SUPPORTIVE_CARE

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* occurrence of injury between 2005 and 2011 * burn surface area (BSA) greater than 10%

Exclusion criteria

* Pregnancy, renal or liver failure, hypo or hyperparathyroidism, prior vitamin D substitution, treatment using systemic corticosteroids or antiepileptic drugs, regular exposure to ultraviolet B radiation (solarium), unstable cardiovascular disease or acute muscle or skeletal injury prohibiting physical exercise

Design outcomes

Primary

Measure	Time frame
calcidiol blood concentration	at the end of the protocol (after one year)

Secondary

Measure	Time frame	Description
bone health	at the end of the protocol (after one year)	bone formation and resorption markers (blood concentrations) bone mineral density measurement using dual energy X-ray absorptiometry
muscle strength	at the end of the protocol (after one year)	Measurements of knee muscles strength on an isokinetic dynamometer

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026