Subclinical Hypothyroidism
Conditions
Keywords
Subclinical hypothyroidism, Atherosclerosis, Cardiovascular disease, Endothelial function, Prevention
Brief summary
Hypothyroidism is risk factor in atherosclerotic cardiovascular diseases, but there is a controversy in effect of subclinical hypothyroidism on cardiovascular diseases. We aim to estimate the relation between subclinical hypothyroidism and endothelial dysfunction and the effects of levothyroxine therapy on it. Patients with confirmed subclinical hypothyroidism by lab results will be randomized to two groups of treatment with one daily dose of 100 mg Levothyroxine or placebo. The flow-mediated dilation and intima media thickness are evaluated before and after the study.
Interventions
DRUGLevothyroxine
DRUGPlacebo
Sponsors
Isfahan University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* age 18 to 65 * confirmed subclinical hypothyroidism
Exclusion criteria
* receiving of other treatments for hypothyroidism * patients with other major medical disorders * smoking * hyperlipidemia * obesity
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline flow-mediated dilation at 2 months | At baseline and then 2 months after treatment | Flow-mediated dilation will be assessed using standard method with a radiologist unaware to the study arms at baseline and then 2 months after treatment. |
| Change from baseline intima-media thickness at 2 months | At baseline and then 2 months after treatment | Intima-media thickness will be assessed using standard method with a radiologist unaware to the study arms at baseline and then 2 months after treatment. |
Countries
Iran
Outcome results
None listed