Comparison of Analgesic Consumption Between Perioperative ıv Dexamethasone and Added to Femoral Block

The Compare the Effect of Peroperative Intravenous Single Dose Dexamethasone and the Addition of Dexamethasone to Femoral Nerve Block on Postoperative Analgesic Consumption Anf Patient Comfort in Unilateral Total Knee Arthroplasty Patients

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02090790

Enrollment

Registered

2014-03-18

Start date

2014-03-31

Completion date

2014-07-31

Last updated

2014-03-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Pain

Keywords

dexamethasone, femoral block, total knee arthroplasty

Brief summary

the aim of this study was to investigate compare the effect of peroperative intravenous single dose dexamethasone and the addition of dexamethasone to femoral nerve block on postoperative analgesic consumption and patient comfort in unilateral total knee arthroplasty patients

Detailed description

Total knee arthroplasty leads to severe postoperative pain. for postoperative pain control after total knee arthroplasty oral -intramuscular opioids ,patient controlled analgesia intravenous or epidural opioids, single -continuous femoral nerve block involving techniques are used. Dexamethasone is a glucocorticoid of high potency and frequently used perioperative.Dexamethasone to the local anaesthetic solution administered trough in femoral nerve blocks significantly prolonged the analgesic effect of the local anaesthetics used on this blocks.If the analgesic efficacy of systemic treatment with dexamethasone is similar with the use of perineural wich is the safest way should be preferred for systemic use.

Interventions

DRUGiv dexamethasone

2 ml 8 mg iv dexamethasone

DRUGfemoral dexamethasone

2ml 8mg dexamethasone administration added 30 ml 0,5 % bupivacain

DRUGserum physiologic

2 ml iv serum physiologic

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* between 18-65 age * knee arthroplasty * no known allergies to drugs * ASA 1-2 patients

Exclusion criteria

* history of diabetes * history of chronic pain treatment * pregnancy * severe bronchopulmonary disease * systemic opioid and steroid use

Design outcomes

Primary

Measure	Time frame
visual analog scale	postoperative 2 day

Secondary

Measure	Time frame	Description
analgesic consumption	postoperative 2 day	morphine consumption (patient controlled analgesia procedure)

Countries

Turkey (Türkiye)

Contacts

Primary Contactahmet öner, resident

dr_ahmetoner@hotmail.com+9055059504112

Backup Contactgülen güler, prof

gulen@erciyes.edu.tr+905327922484

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026