Telangiectasis
Conditions
Keywords
Nasal telangiectasis
Brief summary
The aim of this study is to compare the efficacy of various treatment options for eliminating nasal telangiectasias. The study will compare the outcome of treating nasal telangiectasias with the following; no treatment (control site), alexandrite laser, pulsed dye laser, combination pulsed dye laser and Nd:YAG 1064nm multiplex laser system and electrosurgery.
Interventions
DEVICEPulsed Dye Laser
Pulsed dye laser treatments will be performed with a 595 nanometer wavelength, 20 millisecond pulse duration, at 10 Joules/cm2, with a 10 millimeter spot size.
DEVICELong Pulsed Alexandrite Laser
Alexandrite laser will be used with a 755 nanometer wavelength, 40 millisecond pulse duration, at 88Joules/cm2, with a 6 millimeter spot size.
DEVICEPulsed Dye Laser Plus Nd:YAG Laser
The Cynergy with MultiPlex will be used with a multiplex mode system with a pulse dye laser at 585 nanometer wavelength, 20 milliseconds pulse duration, at 7 Joules/cm2 with a 7 millimeter spot size, with a short delay, followed by a Nd:YAG 1064 nanometer wavelength, 20 millisecond pulse duration, at 50 Joules/cm2 with a 7 millimeter spot size.
PROCEDUREElectrodesiccation
A curette is used to scrape off the cancer down to the dermis. The scraping is then paused while an electrosurgical device like a hyfrecator is used next. Electrodesiccation is performed over the raw surgical ulcer to denature a layer of the dermis and the curette is used again over the surgical ulcer to remove denatured dermis down to living tissue.
Sponsors
University of California, Davis
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Over 18 years of age * Able to give informed consent themselves * Willing to return for follow up visit * 0.5 - 3 millimeter Vessel size * 5 Non-contiguous nasal vascular lesions
Exclusion criteria
* Mentally handicapped * Unable to understand written and oral English * Incarceration * Under 18 years of age * Unwilling to return for follow up * Pregnant Women * Vessels less than 0.5 millimeter caliber * Less than 5 non-contiguous vessels
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Reduction of Area of Nasal Telangiectasias by Laser Therapy Vs Electrosurgery | 3 months | The study will measure the changes in length and width (area) of nasal telangiectasias before and after treatment with the following: no treatment (control site), alexandrite laser, pulsed dye laser, combination pulsed dye laser and Nd:YAG 1064nm multiplex laser system and electrosurgery. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of Cosmetic Improvement | 3 months | Percent perceived improvement for nasal vessels by the patient via questionnaire. |
Countries
United States
Outcome results
None listed