Breast Cancer
Conditions
Keywords
total intravenous anesthesia, inhalation anesthesia, cancer cell cytotoxicity, breast tumor
Brief summary
The purpose of this study is to compare the effect of total intravenous anesthesia and inhalation anesthesia on cancer cell cytotoxicity, micrometastasis and recurrence of tumor in patients undergoing breast tumor resection. Using propofol-remifentanil in total intravenous anesthesia group and sevoflurane -remifentanil in inhalation anesthesia group.
Interventions
PROCEDUREintravenous anesthesia
total intravenous anesthesia group: propofol-remifentanil
PROCEDUREinhalation anesthesia
inhalation anesthesia group: sevoflurane-remifentanil
DRUGsevoflurane-remifentanil
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* patient between 20 and 65 of age with ASA physical status Ⅰ-Ⅲ * breast cancer patients with no sign of local invasion (adjacent organs) and distant metastasis revealed by imaging studies * surgery performed by the same surgical team
Exclusion criteria
* ASA physical status Ⅳ * hepatic and renal impairment * diabetes or other endocrine disorders * body mass index \> 35 kg/m2 * immune disorders or immunosuppressive therapy * steroid treatment in the last 6 months * inflammation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| number of NK cell | at 24 hour after surgery. | comparison of the effect of total intravenous anesthesia and inhalation anesthesia on cancer cell cytotoxicity |
Countries
South Korea
Outcome results
None listed