Candidemia
Conditions
Keywords
candidemia, children, mortality, risk factors
Brief summary
Candidemia has emerged as an important cause of hospital-associated blood-stream infection in children. The purpose of this study was to identify differences in distribution of candida species, risk factors, treatment, and clinical outcome of candidemia in children. This study in children ≤18 years with blood culture proven candidemia identified between 2004 and 2012. Analyses included the determination of causative candida species, resistance to antifungals and clinical outcome, as well as the identification of potential risk factors associated with candidemia.
Interventions
None listed
Sponsors
Hacettepe University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Days to 18 Years
Healthy volunteers
No
Inclusion criteria
* Presence of growth of any candida species in at least one blood culture
Exclusion criteria
* Febrile neutropenic patients who were using empirical antifungal agents
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Risk factors of candidemia | up to 3 months | The presence or absence of potential risk factors for candidemia such as an indwelling central venous catheter (CVC), use of antibiotics (administered for \>72 hours), use of antifungals (administered for \>24 hours), immunosuppressants, total parenteral nutrition (TPN), admission to the intensive care unit (ICU), mechanical ventilation, neutropenia, hypoalbuminemia and hypophosphatemia. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Prognosis according to candida species | up to 3 months | Death which ensues within 30 days of the onset of candidemia with no apparent alternative cause is recognized as a candidemia-attributable mortality. Patients who died and survived were compared according to candida species (C.albicans, C. parapsilosis, C. tropicalis, C. sake, C.glabrata). |
Countries
Turkey (Türkiye)
Outcome results
None listed