Anorexia Nervosa
Conditions
Brief summary
After discharge from inpatient treatment, 30-50% of patients with Anorexia Nervosa require re-hospitalization within 4-12 months. So far, high relapse rates are mostly considered as lack of the patient's compliance and motivation to recover. However in studies, psychological relapse predictors explain only a minor part of the variance in relapse risk. Metabolic phenotyping has clinical value to predict weight course in obese patients and we assume that it could also be clinically relevant in patients with AN. We hypothesize that in patients with a dissipative but not with the thrifty phenotype, positive energy balance during refeeding causes an over proportional rise in energy expenditure, counteracts continuous weight gain during inpatient treatment, and increases relapse risk within one year after discharge. Thus we believe that metabolic phenotype as a biological parameter has prognostic value for the disease course in AN.
Interventions
None listed
Sponsors
Deutsche Forschungegemeinschaft
Charite University, Berlin, Germany
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
12 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* Diagnosis of Anorexia Nervosa * Between 12 and 18 years of age * Written and informed consent of patient and parents * Mental ability to understand the concept of the study * Inpatient admission to Charité University Clinic with body weight below the 10th BMI-Percentile
Exclusion criteria
* Any further disease other than AN with significant influence on body composition and energy metabolism or its assessment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relapse | 1 year after discharge |
Secondary
| Measure | Time frame |
|---|---|
| Metabolic phenotype | Baseline (during inpatient stay) |
| Biomarkers | Baseline (during inpatient stay) |
Countries
Germany
Outcome results
None listed