Chronic Heart Failure
Conditions
Brief summary
Patients with CHF benefit from heart rate lowering, and the investigators have previously demonstrated that this does not adversely affect exercise tolerance. In a pacemaker population we also have shown that preventing heart rate lowering is detrimental in terms of symptoms and prognosis. The aim of the study is to therefore to establish whether heart rate limitation in patients with heart failure has a negative impact on exercise capacity. If the investigators establish that this is not the case, physicians will be able to confidently prescribe heart rate lowering agents, and programme pacemakers to allow bradycardia without the concern that there will be detrimental effects of symptom.
Interventions
DRUGivabradine
DRUGPlacebo
OTHERExercise
Sponsors
The Leeds Teaching Hospitals NHS Trust
Study design
Primary purpose
TREATMENT
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Able to walk on a treadmill Able to provide consent Heart failure (or not) depending upon the arm. Patients with atrial fibrillation to have had an AV node ablation (or very slow response to AF)
Exclusion criteria
* Cognitive impairment, known reaction to ivabradine, musculoskeletal issues limiting walking on a treadmill.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Examining the effects of iatrogenic CI on exercise capacity | 24 months | Each subject will undergo a full echocardiographic examination.We will assess LV systolic and diastolic function variables, mitral regurgitation, and pulmonary artery pressure. |
Countries
United Kingdom
Contacts
Primary ContactKlaus Witte, FRCP, MD
Outcome results
None listed