Effect of Bariatric Surgery on Cognition, Genetics and Lifestyle

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02085369

Enrollment

100

Registered

2014-03-12

Start date

2014-01-31

Completion date

2023-12-31

Last updated

2021-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity, Morbid

Keywords

Bariatric surgery, Cognitive function, Gene expression, Metabolomics, Obesity, Overweight, Lifestyle

Brief summary

Obesity bariatric surgery patients usually lose more than 50% of their former obesity within a relatively short time (\ 2 years). There is still a lack of knowledge about underlying psychological and biological mechanisms of decline in body weight. The intention of this project is to investigate whether bariatric surgery is associated with patients' cognitive ability, lifestyle and/or gene expression and metabolomics.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* First bariatric surgery

Exclusion criteria

* More than one surgery

Design outcomes

Primary

Measure	Time frame	Description
Changes in gene expression profile (a.o. FTO, BDNF) following a standardized meal (before vs. after surgery)	1 year	Gene expression profiling (whole genome analysis, with first interest in FTO and BDNF expression) to assess changes in gene expression before vs. after surgery, and to associate gene expression with weight loss after surgery

Secondary

Measure	Time frame	Description
The effect of bariatric surgery on cognitive functioning (inhibitory control, selective attention)	Measures 1 y, 2 y, and 5 y after surgery.	No-Go go task (to assess inhibitory control) and Stroop tasks (to assess selective attention) will be measured to assess change in these cognitive functions before vs. after surgery, and to associate cognitive functioning with weight loss after surgery

Countries

Sweden

Contacts

Primary ContactMagnus Sundbom, MD

magnus.sundbom@akademiska.se

Backup ContactDidi Nordberg, MSc

didi.nordberg@gmail.com

Outcome results