Application of Combined Lumbar Plexus and Sciatic Nerve Block

Application of Combined Lumbar Plexus and Sciatic Nerve Block in Unilateral Knee Replacement

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02084368

Enrollment

Registered

2014-03-12

Start date

2014-01-31

Completion date

2014-02-28

Last updated

2014-09-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia

Keywords

combined lumbar plexus and sciatic nerve block，, combined spinal and epidural anesthesia

Brief summary

The research is to study the effectiveness and safety of combined lumbar plexus and sciatic nerve block by the guide of peripheral nerve stimulator (PNS) in unilateral knee replacement.There have be some papers which supported that combined lumbar plexus and sciatic nerve block may be more suitable for the old men.

Interventions

PROCEDURENerve block

Patients in this group were assigned to receive lumbar plexus block and sciatic nerve block both using 0.33% ropivacaine 30ml guided by PNS

PROCEDURECombined spinal and epidural anesthesia

Combined spinal and epidural anesthesia were performed in patients of this group with 0.5% hyperbaric bupivacaine 8\ 10mg at L2-3 or L3-4.

DRUGRopivacaine

Patients will be assigned to receive lumbar plexus block and sciatic nerve block both using 0.33% ropivacain 30ml guided by PNS.

DRUGBupivacaine

Combined spinal and epidural anesthesia will be performed in patients with 0.5% hyperbaric bupivacaine 8\ 10mg.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Yes

Inclusion criteria

1. Patients of American Association of anesthetists（ASA）Grade 1、2 or 3 2. Aged between 18 and 85 years 3. Undergoing elective total knee replacement.

Exclusion criteria

1. Mental illness can not match 2. Nerve block, epidural anesthesia contraindicated 3. People who have Slow-type arrhythmias 4. History of chronic headaches and long-term use of analgesic drugs 5. People who were postoperative consciousness, language or hearing impaired

Design outcomes

Primary

Measure	Time frame	Description
Maintenance time of sensory and motor nerve block	up to 24h after operation	from the end of injection of local anesthetic drug up to 24h after operation

Secondary

Measure	Time frame	Description
The change of hemodynamics	0, 5, 10, 20, 30, 60 min after injection	the changes of SBP and DBP at 0, 5, 10, 20, 30, 60 min after injection

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026