Screening of Susceptibility Genes in Postoperative Cognitive Dysfunction(POCD)

Screening of Susceptibility Genes in Postoperative Cognitive Dysfunction After On-pump Cardiac Surgery

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02084030

Enrollment

120

Registered

2014-03-11

Start date

2013-03-31

Completion date

2014-09-30

Last updated

2014-08-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Surgery Patients

Keywords

cardiac surgery, POCD, GWAS, Susceptibility gene

Brief summary

The aim of this study is to perform a whole-genome linkage analysis for identification of the susceptibility loci for POCD

Detailed description

BACKGROUND: Postoperative cognitive dysfunction is probably the most frequent type of postoperative cognitive impairment. As it mainly affect the elderly population, POCD is receiving increasing attention. However, the pathophysiology of POCD remains incompletely understood. No study had elucidate why somebody are apt to suffer from POCD, but others not. In current study, we try to use GWAS technology to find out whether there is a correlation between POCD and gene specificity. DESIGNING: 120 patients will be screened who are schedule to receive selective on-pump cardiac surgery， 5 ml blood of the patient will be collected before anesthesia induction. Investigetors will measure the cognitive function of the patients one day before surgery and 7 d after surgery and identify whether the patient suffer from POCD used in MMSE test. Randomly select 36 patients who suffer from POCD and 36 patients without POCD(control), GWAS technology will be used to screen the susceptibility gene between these two groups. EXPECTED RESULTS ：Find out some susceptibility genes correlate to POCD. CONCLUSIONS: The patients who are apt to suffer from POCD have some special susceptibility genes differ from normal people.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

60 Years to 75 Years

Healthy volunteers

Inclusion criteria

1. Age from 60 to 75 years old; 2. Schedule for on-pump cardiac surgery; 3. undergoing full intravenous anesthesia; 4. without hepatic, renal, pulmonary disease or full intravenous anesthesia surgery history; 5. Gave the informed consent.

Exclusion criteria

1. Emergency surgery; 2. A history of cerebrovascular disease; 3. The history of mental disease; 4. Long term use of sedative and antidepressant drugs; 5. Alcoholism; 6. serious vision, hearing impairment and inapprehensive language; 7. chromosomal abnormalities; 8. blood disease; 9. refused to sign the informed consent.

Design outcomes

Primary

Measure	Time frame
single nucleotide polymorphisms(SNPs) of each patient	about 10 minutes before anesthesia induction

Secondary

Measure	Time frame	Description
mini-mental state examination scale	one day before surgery, 7 d after surgery	the cognitive function

Countries

China

Contacts

Primary ContactHailong DONG, MD, PhD

hldong6@hotmail.com86-2984775337

Outcome results