Premature Baby 25 to 32 Weeks
Conditions
Keywords
premature baby, MRI : conventional and advanced images, Executive function testing at 5 years of age
Brief summary
The survival of premature babies increased during the last decades. However, the neurocognitive long term development of these children is worrying, as demonstrated by EPIPAGE 1 study. These children present high risk of deficits such as cognitive deficits, adaptive malfunction, behavior disorders and difficulties in school learning. Understanding the specific neuropsychological disorders at the origin of these deficits is an important objective. Studies realized at school age showed that many premature children have executive functions (EF) disorders. However the specific nature of these disorders and the neuropathology associated are unknown. The aim of this study is to realise MRI at term age in preterm babies born less than 32 GA and to correlate MRI findings with executives functions and neurodevelopmental outcome
Detailed description
An MRI would be realized between 39 and 41 GA At the age of 5 years, executive functions and neurodevelopmental testing would be realized. 600 newborns were recruited.
Interventions
PROCEDUREterm MRI, executive EF functions testing
An MRI will be realized at term born between 25 and 32 weeks GA
Sponsors
University Hospital, Tours
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
25 Weeks to 32 Weeks
Healthy volunteers
No
Inclusion criteria
Infants who were : * born between 25 and 32 WGA * hospitalized in a neonatology service which participate to the present study * included in EPIPAGE 2 follow-up study * infants whose parents had signed the consent agreement and benefit from national health insurance
Exclusion criteria
* Infants with congenital abnormalities
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Executive functions evaluation at age of 5 and comparison with conventionnal and advanced MRI imagings | During the 5 years follow up |
Secondary
| Measure | Time frame |
|---|---|
| Perinatal risk factors and cerebral lesions as assessed on MRI | During the 5 years follow up |
| Perinatal risk factors and executive and cognitive functions evaluated at 5 years of age | During the 5 years follow up |
Countries
France
Outcome results
None listed