Acute Coagulopathy, Blood Coagulation Disorders, Trauma
Conditions
Keywords
Massive Transfusion Protocol
Brief summary
The purpose of the study is to evaluate the efficacy of the University of Rochester Medical Center's current Massive Transfusion Protocol. Upon arrival of trauma level one designated patients the treating team evaluates the patient's injuries. If the patient is initiated under the facilities Massive Transfusion Protocol and meets other inclusion and exclusion criteria the patient will be enrolled in the study. Study procedures include collection of a blood sample following the transfusion of each shipment, through shipment 5, of blood products outlined in the current Massive Transfusion Protocol. Each blood sample will be run on a Thromboelastograph to evaluate the patient's hematostatic state through resuscitation. One final blood sample will be collected 24 hours following the discontinuation of the Massive Transfusion Protocol and also ran on the thromboelastograph. Due to the critical need for medical intervention, consent procedure will be waived at time of enrollment. An authorized representative for the patient will be identified and approached to obtain consent for use of data collected.
Interventions
OTHERBlood collection
After transfusion of each shipment of blood products outlined in the current Massive Transfusion Protocol one 2.7mL citrated blood sample will be collected from the subject through the 5th shipment of blood products. A final sample will be collected 24 hours following the discontinuation of the massive transfusion protocol.
Sponsors
University of Rochester
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Trauma level 1 patient initiated under Massive Transfusion Protocol * Age greater than or equal to 18 years old
Exclusion criteria
* Females who are pregnant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Efficacy of Blood product ratio | 24 hours | Through thromboelastography testing the coagulopathy of trauma 1 patients receiving massive amounts of blood products in a ratio previously established by the institutions Standard of Procedure will be evaluated to determine the efficacy of the current blood product ratio. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Haemostasis clot kinetics | 24 hours | Kinetics of clot formation analyzed by thromboelastograph over the course of the first 24 hours of resuscitation. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Standard clinical data | 24 hours | Patient and trauma specific information will be extracted from the patients' record. Including but not limited to age, gender, type of injury and severity score, assessment of blood consumption score, blood type, number and volume of blood transfusions consumed during present trauma, current and past medical history and medications. |
Countries
United States
Outcome results
None listed