NAFLD
Conditions
Brief summary
Non-alcoholic fatty liver disease (NAFLD) is characterized by an accumulation of fat in the liver, which is one of the most common forms of chronic liver disease in developed countries. In western countries, the prevalence of NAFLD in the general population is estimated to be 20-30%; in obese populations, this increases to 57.5-74%. But, it hasn't been clearly elucidated yet regarding the underlying disease pathophysiology and treatmet strategy. Recently, members of the C1q/tumor necrosis factor-related protein (CTRP) family have been reported to share structural homology with adiponectin. To date, 15 CTRP family members have been found that might play major roles in glucose metabolism and inflammation. The investigators tried to clarify the relationship between CTRP family and NAFLD in Korean men and women.
Interventions
None listed
Sponsors
Korea University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* 20\<age\<80 * apparently healthy subjects
Exclusion criteria
* a history of CVD * diabetes * stage 2 hypertension * malignancy * severe renal or hepatic disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| serum concentration of CTRP-1, 3, or 9 in the subjects with/without NAFLD | at enrollment |
Secondary
| Measure | Time frame |
|---|---|
| The relationships of serum CTRPs/adiponectin levels with cardiometabolic risk profiles | at enrollment |
Countries
South Korea
Contacts
Primary ContactHo Cheol Hong, M.D.
Backup ContactKyung Mook Choi, M.D.
Outcome results
None listed