Anesthesia, Hypotension
Conditions
Keywords
dexmedetomidine, controlled hypotensive anesthesia
Brief summary
The aim of this study was to evaluate the positive anesthetic properties such as reduce intraoperative analgesic requirement, time to extubation and recovery, and early postoperative pain of dexmedetomidine used as a hypotensive agent compared with nitroglycerin.
Detailed description
The subject included the healthy patients who underwent orthognathic surgery and gave written the informed consent. The sample size was calculate from the amount of fentanyl use in orthognathic surgical case and difference more 30% was significant. Randomization was done by random number table to 2 groups. Both groups received standardized controlled hypotensive anesthesia and surgery. D group used dexmedetomidine as the hypotensive drug and N group use nitroglycerin. The main outcome were the amount of fentanyl use, time to eye opening, follow simple command, extubation, early postoperative pain, and early postoperative amount of pain killer. All recorded by anesthesiologist on data sheet. compare statistical analysis used compare mean by unpaired student t test.
Interventions
DRUGDexmedetomidine
controlled hypotensive anesthesia with dexmedetomidine compare with nitroglycerin on anesthetic outcome such as analgesic use, time to eye opening, follow verbal command, extubation and early postoperative pain
DRUGNitroglycerin
controlled hypotensive anesthesia with nitroglycerin compared with dexmedetomidine on anesthetic outcomes such as analgesic use, time to eye opening, follow verbal command, extubation, and early postoperative pain.
Sponsors
Mahidol University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* patients who undergo bimaxillary surgery physical status I according to the classification of the American Society of Anesthesiologist age 18-45 years
Exclusion criteria
* systemic diseases not given informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| amount of intraoperative fentanyl | intraoperatve period | Record the amount of fentanyl used in the operation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| time to follow verbal command | emergence of anesthesia | the time that counted from closed anesthetic drugs and reversed muscle relaxant to patients can follow simple verbal command such as open mouth, protrude the tongue, move the hand. |
| time to extubation | emergence of anesthesia | the time that counted from closed anesthetic drugs and reversed muscle relaxant to remove the nasotracheal tube. |
| time to eye opening | emergence of anesthesia | the time that counted from closed anesthetic drugs and reversed muscle relaxant to patients eye opening. |
| postoperative pain score at 60 minute | early postoperative period | postoperative pain score at 60 minute using 10-point pain assessment scale. |
| amount of pethidine | early postoperative period (first 2 hours) | Record the amount of pethidine that used for a pain killer when pain score more than 4 in first 2 hours post-operation. |
| postoperative pain score at 30 minute | early postoperative period | postoperative pain score at 30 minute using 10-point pain assessment scale. |
Countries
Thailand
Outcome results
None listed