Overweight, Obese
Conditions
Keywords
low calorie diet, BMI, sphingomyelin, L-leucine, L-phenylalanine
Brief summary
The effect of weight loss with long-term low calorie diet (LCD) on plasma metabolites is unknown. The aim was to examine whether a LCD-induced weight reduction results in changes in the extended plasma metabolites.
Detailed description
Overweight/obese subjects (25≤ BMI \<33 kg/m2) aged 40 to 59 years consumed a LCD (an approximate 100 kcal/day calorie deficit) or a weight-maintenance diet (control) in a randomized, controlled design with 3-year intervention period.
Interventions
DIETARY_SUPPLEMENTLCD
approximate 100 kcal/d caloric deficit
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to 59 Years
Healthy volunteers
No
Inclusion criteria
* 25 \<= BMI \< 33 kg/m2
Exclusion criteria
* type 2 diabetes * cardiovascular disease * psychiatric problems * any medication use
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| anthropometry | 3-year follow-up | weight, height, BMI, waist circumference, blood pressure |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| biochemistry analysis | 3-year follow-up | total-cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, free fatty acids, glucose, insulin, HOMA-IR, Lp-PLA2 |
Other
| Measure | Time frame | Description |
|---|---|---|
| plasma metabolites | 3-year follow-up | palmitic amide, oleamide, lysoPC (16:1, 16:0, 17:0, 18:2, 18:1, 18:0, 20:4, 20:3, 22:6), PC (16:0/20:5, 16:0/20:5, 18:2/18:2, 18:0/20:4), lactosylceramide (d18:1/12:2) |
Countries
South Korea
Outcome results
None listed