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Admission HbA1C in Aneurysmal Subarachnoid Hemorrhage

Observational Study on the Prognostic Relevance of Admission Glycated Hemoglobin (HbA1C) in Patients With Aneurysmal Subarachnoid Hemorrhage

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT02081820
Enrollment
89
Registered
2014-03-07
Start date
2012-07-31
Completion date
2014-12-31
Last updated
2015-03-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aneurysmal Subarachnoid Hemorrhage, Hyperglycemia

Keywords

hyperglycemia, aneurysmal subarachnoid hemorrhage, glycated hemoglobin, outcome, DCI

Brief summary

In patients suffering from aneurysmal subarachnoid hemorrhage (aSAH), hyperglycemia is considered an adverse prognostic factor. Glycated hemoglobin (or HbA1c) can be measured to estimate the average plasma glucose concentration over prolonged periods of time, thus determination of glycated hemoglobin at admission after aSAH serves as an approximation of blood glucose levels in the weeks preceding aneurysm rupture. In this patient registry admission HbA1c, clinical course and neurological outcome after 6 month are recorded, to determine whether elevated blood glucose levels prior to aneurysm rupture influence the clinical course and patient outcome after aSAH.

Detailed description

In patients suffering from aneurysmal subarachnoid hemorrhage (aSAH), hyperglycemia is considered an adverse prognostic factor. Glycated hemoglobin (or HbA1c) can be measured to estimate the average plasma glucose concentration over prolonged periods of time, thus determination of glycated hemoglobin at admission after aSAH serves as an approximation of blood glucose levels in the weeks preceding aneurysm rupture. In this patient registry admission HbA1c within 72 hours after confirmed aneurysmal subarachnoid hemorrhage in patients aged over 18 years is determined and correlated with clinical course and neurological outcome after 6 month as determined by modified Rankin score. Additionally, patients are monitored for incidence of delayed cerebral ischemia (DCI) and the incidence of new infarction on the discharge ct scan attributable to DCI. General treatment of cerebral aneurysm and subarachnoid hemorrhage in all patients follows international guidelines.

Interventions

None listed

Sponsors

Heinrich-Heine University, Duesseldorf
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* confirmed aneurysmal subarachnoid hemorrhage * admission within 72hours after hemorrhage * Age \>18 years

Exclusion criteria

* non-aneurysmal SAH * admission \>72hours after hemorrhage * Age \<18 years

Design outcomes

Primary

MeasureTime frame
modified Rankin score6 month after discharge

Secondary

MeasureTime frameDescription
Incidence of DCI related new infarction on discharge ct scanat discharge, approx. 14-21days after admissionIncidence of new infarction on discharge ct scan not attributable to causes other then DCI.

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 8, 2026