Aneurysmal Subarachnoid Hemorrhage, Hyperglycemia
Conditions
Keywords
hyperglycemia, aneurysmal subarachnoid hemorrhage, glycated hemoglobin, outcome, DCI
Brief summary
In patients suffering from aneurysmal subarachnoid hemorrhage (aSAH), hyperglycemia is considered an adverse prognostic factor. Glycated hemoglobin (or HbA1c) can be measured to estimate the average plasma glucose concentration over prolonged periods of time, thus determination of glycated hemoglobin at admission after aSAH serves as an approximation of blood glucose levels in the weeks preceding aneurysm rupture. In this patient registry admission HbA1c, clinical course and neurological outcome after 6 month are recorded, to determine whether elevated blood glucose levels prior to aneurysm rupture influence the clinical course and patient outcome after aSAH.
Detailed description
In patients suffering from aneurysmal subarachnoid hemorrhage (aSAH), hyperglycemia is considered an adverse prognostic factor. Glycated hemoglobin (or HbA1c) can be measured to estimate the average plasma glucose concentration over prolonged periods of time, thus determination of glycated hemoglobin at admission after aSAH serves as an approximation of blood glucose levels in the weeks preceding aneurysm rupture. In this patient registry admission HbA1c within 72 hours after confirmed aneurysmal subarachnoid hemorrhage in patients aged over 18 years is determined and correlated with clinical course and neurological outcome after 6 month as determined by modified Rankin score. Additionally, patients are monitored for incidence of delayed cerebral ischemia (DCI) and the incidence of new infarction on the discharge ct scan attributable to DCI. General treatment of cerebral aneurysm and subarachnoid hemorrhage in all patients follows international guidelines.
Interventions
None listed
Sponsors
Study design
Eligibility
Inclusion criteria
* confirmed aneurysmal subarachnoid hemorrhage * admission within 72hours after hemorrhage * Age \>18 years
Exclusion criteria
* non-aneurysmal SAH * admission \>72hours after hemorrhage * Age \<18 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| modified Rankin score | 6 month after discharge |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of DCI related new infarction on discharge ct scan | at discharge, approx. 14-21days after admission | Incidence of new infarction on discharge ct scan not attributable to causes other then DCI. |
Countries
Germany