Consolidation & Interference in Multiple Sclerosis

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02081508

Enrollment

Registered

2014-03-07

Start date

2014-03-31

Completion date

2015-05-31

Last updated

2016-08-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis

Keywords

Memory

Brief summary

The purpose of this research study is to investigate whether minimizing interference improves memory in multiple sclerosis.

Detailed description

The ability to form new long-lasting memories is important for successful independent living and a high quality of life. Roughly half of the individuals diagnosed with Multiple Sclerosis (MS) have difficulty remembering new information and this is likely associated with poor acquisition of new information. There are only a limited number of studies that have investigated memory consolidation in MS. The current study will investigate the role of interference during the consolidation time period of memory formation.

Interventions

BEHAVIORALInterference onset

Temporal duration of interference onset.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* If you are between the ages of 18-65. * If you have a diagnosis of Multiple Sclerosis (MS) or are medically healthy. * If you have MS, you have not had a flare up of MS symptoms in the past month. * You do not have other neurological issues such as, Epilepsy or Stroke. * You do not have a significant history of psychiatric problems or a current diagnosis of Major Depressive Disorder, Schizophrenia, Bipolar Disorder . * You do not have a significant history of drug or alcohol abuse. * You can read and speak English fluently. * You are not currently taking steroids.

Exclusion criteria

* You are younger than 18 years old. * You are older than 65 years old. * You have had a prior stroke or neurological disease other than MS. * You have a history of significant psychiatric illness (for example, bipolar disorder, schizophrenia, or psychosis) or a current diagnosis of Major Depressive Disorder, Bipolar Disorder. * You have a significant alcohol or drug abuse history. * You are currently taking steroids.

Design outcomes

Primary

Measure	Time frame
Recall Proportion	2 hours

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026