Refractory Chronic Cluster Headache
Conditions
Brief summary
The occipital nerve stimulation (ONS) is used to treat patients with refractory primary chronic headache but its mechanism of action (MoA) remains unknown. Different hypothesis have been suggested in particular a specific action on cerebral generators involved in different types of primary headaches or a non specific action on pain modulatory network. The aim of this study, using the chronic cluster headache as a model, is to determine the changes in cerebral metabolism induced by ONS to precise its MoA in the treatment of primary chronic headache.
Interventions
RADIATION18F-FDG PET
Sponsors
Centre Hospitalier Universitaire de Nice
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age \> 18 years * chronic cluster headache (according to the IHS) * refractory in who a treatment by ONS have been indicated * patient affiliated at social security, * informed consent signed
Exclusion criteria
* contraindication to MRI * contraindication to 18F-FDG PET * women without contraception/pregnant/breast-feeding * patient non-compliant * patient on legal guardianship
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of cerebral metabolism | Baseline (before ONS), 1 week after ONS , 3 month after ONS | Changes of cerebral metabolism associated with ONS efficacy |
Countries
France
Outcome results
None listed