Hypoxemia
Conditions
Keywords
hypoxemia, high flow oxygen therapy, respiratory failure
Brief summary
Patients with respiratory failure often need oxygen and/or ventilatory support. Patients who need only oxygen support, usually received low flow oxygen (\< 15 Liters / min), as well as in respiratory weaning. Now new devices can be used. They provide high flow oxygen with different benefits. This high flow devices provide exact fraction of inspired oxygen (FiO2), allows a positive end expiratory pressure and supplies a wash out flow. The hypothesis of this study is that the high flow oxygen enable more efficient oxygen administration than conventional oxygen. In addition, it would improve the effectiveness of the ventilation of the patient, through flushing the dead space.
Detailed description
The investigators hypothesized that when using high flow oxygen therapy, respiratory failure is relieved, as well as ventilation failure, so accessories are less stressed muscles, and this can be demonstrated by the electromyography (EMG) of sterno-mastoid..
Interventions
DEVICEOptiflow
patients receive oxygen via high flow oxygen therapy during 20 minutes
Sponsors
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
patients with respiratory failure. * Spontaneously breathing patient requiring administration at least 40% oxygen, or, * Patient under mechanical ventilation, during respiratory weaning.
Exclusion criteria
* Facial trauma, active hemoptysis, pneumothorax, thoraco-abdominal surgery or upcoming intubation for spontaneously breathing patients. * Neuromuscular disease, altered consciousness or agitation for patients under mechanical ventilation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in Oxygenation criteria | 20 minutes | Arterial oxygen partial pressure (PO2), oxygen saturation by pulse oximetry (SpO2), arterial PO2/FiO2, positive end expiratory pressure (PEEP) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in Ventilation criteria | 20 minutes | respiratory rate (RR), arterial partial CO2 pressure (PCO2), pH, sterno-mastoid EMG |
Other
| Measure | Time frame | Description |
|---|---|---|
| change from baseline in hemodynamic criteria | 20 minutes | cardiac frequency, arterial blood pressure |
Outcome results
None listed