Deceased Donor Kidney Transplantation, Living Donor Kidney Transplantation
Conditions
Keywords
kidney transplantation, delayed graft function, creatinine, graft survival
Brief summary
It is required to establish an adequate definition of delayed graft function in deceased donor kidney transplantation. We attempt to compare various definitions of delayed graft function and find the definition that can predict graft function survival best in deceased donor kidney transplantation.
Detailed description
Delayed graft function after kidney transplantation has been reported to be an important predictor for poor short and long-term survival. Delayed graft function increases post-transplantation morbidity, hospital stay, and incidence of premature graft failure. However, the definition of delayed graft function varies and more than ten definitions have been used in previous studies. Although the definition using dialysis requirements during seven days after transplantation has been used most frequently, dialysis may be required without any evidence of renal damage during one week after transplantation. Furthermore, the incidence of delayed graft function in living donor kidney transplantation using this definition has been reported to be relatively low (as low as 1.6%) compared with the incidence in deceased donor kidney transplantation (up to 50%). Therefore, it is required to establish a better definition of delayed graft function in deceased donor kidney transplantation. We attempt to compare various definitions of delayed graft function in deceased donor kidney transplantation and find the definition that can predict graft function survival best in deceased donor kidney transplantation.
Interventions
PROCEDUREkidney transplantation, living or deceased donor
Sponsors
Samsung Medical Center
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* patients who underwent living or deceased donor kidney transplantation between 2008 and 2013
Exclusion criteria
* incomplete data of postoperative creatinine during ten days after transplantation or postoperative urine output during three days after transplantation * patients who underwent retransplantation * patients who expired for reasons other than kidney transplantation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| delayed graft function as defined by dialysis requirements within one week after transplantation | during 7 days after transplantation | delayed graft function as defined by dialysis requirements within one week after transplantation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| delayed graft function as defined by serum creatinine decrease less than 10% during 48 hours after transplantation | during 48 hours after transplantation | delayed graft function as defined by serum creatinine decrease less than 10% during 48 hours after transplantation |
| delayed graft function as defined by urine output less than1200 ml during first day after transplantation | during 24 hours after transplantation | delayed graft function as defined by urine output less than1200 ml during first day after transplantation |
| delayed graft function as defined by creatinine greater than 2.5 mg/dL at ten days after transplantation | after ten days after transplantation | delayed graft function as defined by creatinine greater than 2.5 mg/dL at ten days after transplantation |
| delayed graft function as defined by creatinine clearance less than 10 ml/min/1.73m2 during 24 hours after transplantation | during 24 hours after transplantation | delayed graft function as defined by creatinine clearance less than 10 ml/min/1.73m2 during 24 hours after transplantation |
| delayed graft function as defined by creatinine did not decrease less than preoperative value | during one week after transplantation | delayed graft function as defined by creatinine did not decrease less than preoperative value |
Other
| Measure | Time frame | Description |
|---|---|---|
| immediate graft function | after eight days after transplantation | immediate graft function after eight days after transplantation (defined as serum creatinine decrease less than 70% of preoperative value) |
| slow graft function | at eight days after transplantation | slow graft function at eight days after transplantation (defined as serum creatinine greater than 70% of preoperative value) |
| Mortality | one month, six month, and one year after transplantation | Mortality after one month, six month, and one year after transplantation |
| graft survival | one month, six month, and one year after transplantation | graft survival one month, six month, and one year after transplantation |
Countries
South Korea
Outcome results
None listed