Liver Transplantation, Renal Function
Conditions
Keywords
risk factor, acute kidney injury, liver transplantation, postoperative renal function
Brief summary
The incidence of acute kidney injury after liver transplantation has been reported to be 17 to 95 percent, but no definite treatment has been reported yet. Therefore, it is important to identify and prevent reversible risk factors for acute kidney injury after liver transplantation. Previous studies have reported several preoperative clinical risk factors, but preoperative medication and intraoperative colloid administration and hemodynamic parameters have not been evaluated. Therefore, we attempt to evaluate perioperative risk factors and develop simplified clinical risk scoring model.
Detailed description
Ischemia/reperfusion injury occurs during graft harvesting, cold storage, and surgical procedures in liver transplantation. Ischemia/reperfusion injury in liver graft results in major organ damage including kidney, lung and heart as well as graft dysfunction. Graft dysfunction and renal injury after liver transplantation are major clinical issues and are associated with prognosis and low survival rate. The incidence of acute kidney injury after liver transplantation has been reported to be 17 to 95 percent, but no definite treatment has been reported yet. Therefore, it is important to identify and prevent reversible risk factors for acute kidney injury after liver transplantation. Previous studies have reported several preoperative clinical risk factors, but perioperative medication, metabolic variables (albumin, glucose, uric acid), intraoperative colloid administration and hemodynamic parameters have not been evaluated. In addition, a neutrophil-lymphocyte ratio (NLR), which has been reported to be related to systemic inflammation and associated with prognosis of cardiac and cancer patients, might be related to the development of AKI after LDLT. Therefore, we attempt to evaluate these perioperative risk factors and develop simplified clinical risk scoring model.
Interventions
PROCEDUREliving donor liver transplantation
Sponsors
Samsung Medical Center
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Patients who underwent living donor liver transplantation between 2010 and 2013 in Samsung Medical Center
Exclusion criteria
* Incomplete data regarding pre- and postoperative creatinine and estimated Glomerular Filtration Rate * patient who underwent retransplantation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| acute kidney injury as defined by RIFLE criteria | during 7 days after transplantation | acute kidney injury as defined by RIFLE criteria |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| incidence of renal replacement therapy | during one month after transplantation | renal replacement therapy |
| incidence of acute rejection of graft | during one month after transplantation | incidence of acute rejection of graft |
| incidence of initial poor graft function | during one month after transplantation | incidence of initial poor graft function |
| incidence of retransplantation | during one month after transplantation | incidence of retransplantation |
Other
| Measure | Time frame | Description |
|---|---|---|
| Mortality | during one month, six month, one year | Mortality during one month, six month, one year |
Countries
South Korea
Outcome results
None listed