Pulmonary Disease, Chronic Obstructive
Conditions
Keywords
COPD, portable concentrator, oxygen sources
Brief summary
Introduction: Portable oxygen devices simplify and facilitate patient therapy. This study was designed to compare oxygen saturation and patient satisfaction with a portable oxygen concentrator or with a combined system consisting of a fixed device with continuous flow oxygen dispensation and a portable device with pulse dispensation for ambulation. Methods: This cross-over trial assessed 25 patients with COPD (92% men; mean age 72.2 ± 7.4 years; mean FEV 34.14 ± 12.51%) at four hospitals in Madrid. All patients had previously used the combined system, consisting of a fixed oxygenation system and a portable system for ambulation, with 16 (64%) using stationary and portable concentrators and 9 (36%) using a stationary reservoir and portable liquid oxygen bag. Oxygenation settings at rest and while walking were determined at baseline. Patients were maintained on the previous combined system for one week and then switched to the portable oxygen concentrator for one week. Mean SpO2 over 24 hours was calculated by the software in the oximeter, and compliance was monitored
Interventions
DEVICEInogen
single pulse dose concentrator (Inogen One G2 portable. Inogen) device for 24 hours
DEVICECombination system of a portable and a stationary device.
Combination system of a portable and a stationary device (reservoir of liquid oxygen Liberator 30, Caire and a liquid Stroller oxygen pack Caire for patients using previously liquid oxygen, or a VisionAire5 Airsep stationary concentrator and an Inogen One G2 portable Inogen concentrator for patients using previously concentrators)
Sponsors
Linde AG
Hospital Son Espases
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* aged 40-80 years * had been diagnosed with COPD following the GOLD criteria * were receiving oxygen therapy using a fixed oxygenation system and a portable system for ambulation * without exacerbation during the previous month * agreed to participate
Exclusion criteria
* terminally ill * unable to understand Spanish * had high oxygen flow at rest (\> 3 lpm) * high respiratory frequency at rest (\> 32 rpm) * were not achieving adequate O2 saturation levels during titration with the portable oxygen source * had previously been diagnosed with obstructive sleep apnea hypopnea syndrome (SAHS) * were receiving mechanical ventilation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of time desaturated below 90% when using a combined oxygenation system | at day 7 | oxygenation of patient during use of a combined system consisting of a fixed device with continuous flow oxygen dispensation and a portable device with pulse dispensation for ambulation. |
| Percentage of time desaturated below 90% using single oxygenation system | day 14 | Oxygenation of patient during use of a portable oxygen pulse dose concentrator. |
Countries
Spain
Outcome results
None listed