The Role of Ninjurin-1 During Systemic Inflammation

Prospective Study to Analyze Ninjurin-1 and Its Soluble Part During Systemic Inflammation

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02079597

Acronym

Ninj1

Enrollment

Registered

2014-03-06

Start date

2014-02-28

Completion date

2014-09-30

Last updated

2014-09-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ninj1 Expression, SIRS

Keywords

SIRS, Ninj1, Sepsis, Healthy

Brief summary

* With the underlying study the investigators address the question if Ninjurin-1 (Ninj1) expression is altered in patients with systemic inflammatory response syndrome (SIRS) in comparison to healthy volunteers. * The adhesion molecule Ninj1 is induced following nerve injury where it contributes to nerve generation. Besides it is described to facilitate leukocyte migration especially in the nervous system. * The investigators hypothesize that Ninj1 expression is increased in SIRS patients, which will fortify its impact during inflammation and the transferability from bench to bedside.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* age \> 18 years * cardiac surgery patients

Exclusion criteria

* included in an interventional study * Preoperative Infection (e.g. Endocarditis)

Design outcomes

Primary

Measure	Time frame
Ninj1 expression on blood leukocytes	one day post surgery

Secondary

Measure	Time frame	Description
grade of systemic inflammation	one day post surgery	routine inflammatory markers will be used to evaluate the grade of inflammation e.g. procalcitonin (PCT) Interleukin 6, lipopolysaccharide (LPS) binding protein (LBP). Retrospective evaluation for sepsis (bacterial infection)

Other

Measure	Time frame	Description
Soluble Ninj1 concentration/expression rates	one day post surgery	Concentration will be measured in plasma samples as well as from whole blood culture incubated with 100 ng/ml lipopolysaccharide for 6, 16 and 24 h.

Countries

Germany

Outcome results