Efficacy of Oxytocin vs. Carbetocin in Prevention of Postpartum Hemorrhage After Cesarean Section

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02079558

Enrollment

220

Registered

2014-03-06

Start date

2012-09-30

Completion date

2013-09-30

Last updated

2014-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postpartum Hemorrhage

Keywords

prevention, cesarean section

Brief summary

Postpartum hemorrhage (PPH) is a common complication of childbirth and a leading cause of maternal morbidity and mortality. The prompt and effective treatment of subjects with PPH would reduce operation risks. Hence in this study, the efficacy of Oxytocin and Carbetocin was compared in prevention of postpartum hemorrhage after cesarean sections.

Interventions

DRUGCarbetocin

Carbetocin with single 100 microg IV dosage was used in this investigation

DRUGOxytocin

Oxytocin with 30 international units (IU) IV infusion was used in this investigation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SCREENING

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

FEMALE

Healthy volunteers

Yes

Inclusion criteria

* At least one risk for postpartum hemorrhage and lack of hypersensitivity to oxytocin and carbetocin

Exclusion criteria

* Patients' refusal to cooperate, major therapeutic side effects, history of cardiac and renal disease or preeclampsia

Design outcomes

Primary

Measure	Time frame
screening of Cessation of bleeding	screening until 24 hours after placenta disconnection
time duration to stop bleeding in the case of post-cesarean section	24 hours

Countries

Iran

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 26, 2026