Heart Failure
Conditions
Brief summary
The number of patients with acute congestion on chronic heart failure is increasing. Ultrafiltration has recently been proposed as an alternative approach for the stabilization of volume balance, especially in patients with imminent diuretic resistance. There is increasing evidence that ultrafiltration may relief cardiac congestion with lesser effects on blood pressure and activation of renin angiotensin system, respectively . However, recent studies revealed conflicting results: demonstration the superiority of ultrafiltration in comparison to diuretic treatment, and a lack of evidence of benefit, as well as an excess of adverse events with ultrafiltration. Aquapheresis with adapted ultrafiltration rate guided by central venous pressure is safer than aquaphesis with a constant ultrafiltration with comparable effectiveness
Interventions
PROCEDUREUltrafiltration
Sponsors
Heinrich-Heine University, Duesseldorf
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with chronic heart failure scheduled for LVAD * Indication for CVVH/Aquapheresis
Exclusion criteria
* Renal Disease (GFR \<20 ml / min)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in central venous pressure | Changes from Baseline to 48 h after intervention |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Measure of dyspnea using a visual analog scale | Changes from Baseline to 48 h after intervention | — |
| heart function | 7 days | right/left heart function measured by Echocardiography and BNP (Brain Natriuretic Peptide) |
| Biomarker | Changes from Baseline to 48 h after intervention | GFR, Cystatin C, HCO3-, NT-proBNP, CK, Troponin, Hematocrit |
| amount of net fluid loss | 48 h | — |
| blood pressure | Changes from Baseline to 48 h after intervention | — |
| heart rate | Changes from Baseline to 48 h after intervention | — |
| Serum Creatinine level | 48 h | — |
| Time until impaired plasma refill rate | 48 h | — |
Countries
Germany
Outcome results
None listed