The PRESS RA: Protein and Resistance Exercise Supplementation Study for Rheumatoid Arthritis

The PRESS RA Study: Protein and Resistance Exercise Supplementation Study for Rheumatoid Arthritis

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02078375

Acronym

PRESSRA

Enrollment

Registered

2014-03-05

Start date

2014-02-28

Completion date

2018-07-01

Last updated

2019-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rheumatoid Arthritis

Keywords

Rheumatoid Arthritis

Brief summary

This study will evaluate if the combination of resistance exercise and protein supplementation will increase muscle strength and muscle mass among older individuals with rheumatoid arthritis (RA).

Detailed description

This study proposes a randomized trial to evaluate a tailored 16-week resistance exercise program, in combination with protein supplementation, for older individuals with RA. The exercise protocol in this study is distinctive because it combines dynamic and isometric (static) resistance exercise performed on specialized equipment that can accommodate the range of motion limitations frequently encountered in the older RA population. This study will also begin to evaluate if additional benefit can be achieved with daily protein supplementation

Interventions

DIETARY_SUPPLEMENTProtein

whey protein plus casein protein

DIETARY_SUPPLEMENTCarbohydrate (Placebo)

The twice daily placebo will consist of a carbohydrate and a small amount of protein

OTHERResistance Exercise Program

All participants will be enrolled in an individually supervised twice weekly (for 16 weeks) resistance exercise program

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

60 Years to 95 Years

Healthy volunteers

Inclusion criteria

* age 60-95 years * diagnosis of rheumatoid arthritis * willing to participate in twice weekly exercise sessions

Exclusion criteria

* cognitive impairment * recent heart surgery (within past 12 months) * severe kidney disease * use of supplemental oxygen * presence of pacemaker * diabetes that requires insulin for management * allergy to soy or milk

Design outcomes

Primary

Measure	Time frame	Description
Body composition	after 16 weeks	measured by dual-energy X-ray absorptiometry (DEXA) (lean mass vs fat mass)
Muscle strength	after 16 weeks	measured by hand grip and biodex

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026