Major Depressive Disorder, Single Episode, Unspecified
Conditions
Keywords
depression，adolescent，attention bias，modification
Brief summary
In this study, we test whether a two-week 8-session neutral attention bias modification (ABM) training and a two-week 4-session positive ABM could reduce depressive symptoms relative to placebo controls in adolescents with major depressive disorder at posttraining and follow-ups during one year.
Detailed description
Depression is a common health problem in adolescents. Negative attentional bias has been theorized to play a critical role in the onset and maintenance of depression, suggesting that reduction of such biases may treat symptoms of depression. Recent studies have shown that attention bias modification(ABM) training could reduce depressive symptoms in both dysphoria and previously depressed adult patients.To test the effectiveness of ABM training on the treatment of depressive symptoms in depressed adolescents, we designed a randomized, double-blind, placebo controlled trial in adolescents with major depressive disorder(MDD).
Interventions
BEHAVIORALABMT
During a two-week period, 8 sessions of a modified dot probe task for attentional bias modification training (ABMT) condition, 8 sessions of a classic dot probe task for placebo training (PT) condition.
Sponsors
Hunan Normal University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
11 Years to 19 Years
Healthy volunteers
No
Inclusion criteria
* Meet the major depression disorder's criteria
Exclusion criteria
* bipolar disorder, schizophrenia or organic mental disorder; * any concurrent psychotherapy; * any concurrent psychotropic medication.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in depressive symptom number | baseline, 7-week, 6-month follow-up | Depressive symptom accounts measured by Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children. |
| Changes in depressive severity | baseline, 7-week, 6-month follow-up | depressive severity measured by the construct interview of the Schedule for Affective Disorders and Schizophrenia for School-Age Children(K-SADS) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of Self-report symptoms | baseline, 7-week, 6-, 12-month follow-up | symptoms measured by the Center for Epidemiological Studies Depression Scale (CES-D), State-Trait Anxiety Inventory-Trait(STAI-T)，Rumination Response Style（RRS)，Suicidal Ideation Questionnaire（SIQ） |
| Diagnostic status of major depressive disorder | baseline, 7-week, 6-month follow-up | Assessed by the diagnostic interview of the Schedule for Affective Disorders and Schizophrenia for School-Age Children |
Countries
China
Outcome results
None listed