To Study the Effect of β-glucans on Wound Healing

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02078128

Enrollment

Registered

2014-03-05

Start date

2011-07-31

Completion date

2013-02-28

Last updated

2014-03-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Burns

Keywords

burn, wound healing, skin graft

Brief summary

The purpose of this study is to determine the effect of β-glucans on wound healing.

Detailed description

The structure of βeta-glucan (β-glucans) is a pathogen associated molecular patterns (pathogen-associated molecular patterns, PAMPs), widely present in the cell walls of plants, bacteria, yeasts, fungi, mushrooms and algae. Modern has been reported in the literature that β-glucan can enhance the immune system of animals, and to enhance the function of the animal against bacterial, fungal and viral infections, and cancer.In this study, the use of β-glucan to enhance the biological characteristics of the non-specific immunity, to explore the impact of postoperative patients with wound healing and infection rates.The observation of the healing process to take the Leather District wounds (5 \ 200 cm2). The experiments were carried out for 18 months, were observed record the following three: (1) the rate of wound healing, (2) The rate of infection assessment: record length of time and the point in time at all levels of antibiotic use also observe the wound change (redness, swelling, heat, pain).(3) days of hospitalization, and spend statistics. Using unpaired student's t-test analysis, group data whether the differences between groups of experimental data. represents a statistically significant when p \<0.05.

Interventions

DIETARY_SUPPLEMENToral beta-glucans

30 mg/kg, oral every day until wound healed completes or unacceptable toxicity develops.

DRUGoral sugar powder

30 mg/kg, oral every day until wound healed completes or unacceptable toxicity develops.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

20 Years to 60 Years

Healthy volunteers

Inclusion criteria

1. Total burn area under 20%, two to three degree burn and need skin-grafting. 2. Subjects don't have other diseases. 3. Subjects' age between 20 to 60.

Exclusion criteria

1. Subjects with hypersensitivity. 2. Subjects with Autoimmune disease.

Design outcomes

Primary

Measure	Time frame	Description
Wound healing percentage	every Monday and Thuresday for the duration of hospital stay, an expected average of 3 weeks	record data by taking picture

Countries

Taiwan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026