Assessment of Blood Pressure Control and Target Organ Damage in Patients With Chronic Kidney Disease and Hypertension -II

Observational Study of Blood Pressure Control Pattern and the Impact on the Target Organ Damages

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02078115

Enrollment

400

Registered

2014-03-05

Start date

2013-04-30

Completion date

2015-07-31

Last updated

2014-03-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Kidney Disease, Hypertension

Brief summary

The purpose of this study is to find the change of blood pressure (BP) control pattern (true controlled, white-coat, masked, and sustained uncontrolled/ dipper, non-dipper, reverse-dipper, and extreme-dipper) in patients with chronic kidney disease (CKD) over 3 years. And Other objective is the relationship between the BP control pattern and the target organ damages such as renal function, proteinuria, left ventricular hypertrophy (LVH), and so on. In addition, we will find clinical factors related to the BP control pattern.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 74 Years

Healthy volunteers

Inclusion criteria

1. with informed consent 2. 20 \<= age \< 75 years 3. diagnosed as hypertension 6 months (or 3 visits) prior to enrollment, taking anti-hypertensive drugs over 3 months 4. all-cause chronic kidney disease patients with 15 \<= estimated GFR \< 90 5. no change of anti-hypertensive drugs within 2 weeks and good compliance

Exclusion criteria

1. changed prescription according to ambulatory blood pressure monitoring (ABPM) regularly 2. had acute kidney injury/hospitalization 3. had a proteinuria of \> 6 g/day (spot urine protein to creatinine ratio \> 6.0 g/g Cr) 4. had end stage renal disease (ESRD) with dialysis and/or were a kidney recipient 5. had diseases, such as uncontrolled arrhythmia, uncontrolled bronchial asthma/chronic obstructive pulmonary disease, or primary endocrinologic diseases except diabetes mellitus 6. were pregnant/lactating women 7. were night shift workers.

Design outcomes

Primary

Measure	Time frame
The change of blood pressure control pattern in patients with CKD	1 year after enrolling the last participant

Secondary

Measure	Time frame
1) target organ damages in kidney and heart	1 year after enrolling the last participant
2) the relationship between the change of BP control pattern and the target organ damages	1 year after enrolling the last participant
3) assessment of related clinical factors with BP control pattern	1 year after enrolling the last participant

Countries

South Korea

Contacts

Primary ContactSung Kyun Kim, MD

imnksk@gmail.com

Outcome results