Cerebral Primitive Tumor With Chirurgical Indication
Conditions
Brief summary
The purpose of this study is to determine the correlation between functional MEG analysis of the tumor and its periphery and the tumor stage and treatment response.
Detailed description
A better tumor grade definition would provide an optimized surgical care, prognosis and therapeutical response evaluation.
Interventions
OTHERMEG and MRI
CONDUCTOME
Sponsors
University Hospital, Grenoble
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* more or equal than 18 years old * patient affiliated to social security or similarly regime * informed consent form signed * supra-tentorial primitive cerebral tumor
Exclusion criteria
* Pregnant women and lactating mothers * Ward of court or under guardianship * Adult unable to express their consent * Person deprived of freedom by judicial or administrative decision * Person hospitalized without their consent * Person under legal protection * Magnetic Resonance Imaging (MRI) contraindication (implanted material non MRI-compatible, ferro-magnetic foreign body, claustrophobia) * Patients needed emergency medical care for other pathology * severely altered general health (Performance Status 3 or 4)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Magnetoencephalography (MEG) and Magnetic Resonance Imaging (MRI) data in tumor grade prediction | 1 week before exeresis |
| anatomopathologic and clinical data in tumor grade prediction | 1 week after exeresis |
Secondary
| Measure | Time frame |
|---|---|
| Measurement of molecules involved in glial cells neuralisation expression in tumor samples | Up to 1 month after surgery |
| Tumoral growth modelisation from patient MEG and MRI data | Up to 1 month after surgery |
Countries
France
Outcome results
None listed