Primary Open-angle Glaucoma
Conditions
Brief summary
Most of the patients under long application of anti-glaucoma eyedrops endure severe ocular surface irritation, which interrupt their quality of life a lot. Lots of studies aimed to search for new drugs for therapy. The investigators hypothesized that the artificial tears containing vitamin A or carbomer may be a great substitute. Both of the two drugs were in common use and had already been tested in animals.
Interventions
DRUGVitamin A
use one drop in the eye
DRUGcarbomer eye gel
use one drop in the eye
Sponsors
Xiaodong Zhou
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
\- diagnosed primary open-angle glaucoma or normal tension glaucoma patients with prostaglandin analogs treatment for more than one year.
Exclusion criteria
1. any systemic diseases which may cause ocular damage; 2. previous ocular trauma or surgery; 3. contact lens wear history in previous 6 months; 4. application of any artificial tears 3 months ago; 5. allergic to any of the drugs we used during examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| change of the density of conjunctival goblet cells | change from Baseline in goblet cell density at 6 months |
Secondary
| Measure | Time frame |
|---|---|
| tear film parameters changes in patients | change from baseline in TBUT and Schirmer test at 6 months |
| changes of ocular irritation in patients | change from baseline in OSDI scores at 6 months |
Outcome results
None listed