Muscle Damage
Conditions
Keywords
compression, isokinetic, far-infrared
Brief summary
To examine the influence of compression garments manufactured with Far-Infrared technology on exercise performance during and after repeated eccentric isokinetic muscle actions of the leg extensors.
Detailed description
Participants: Eighty recreationally active (1-5 hrs per week) healthy participants between the ages of 18 - 35 will visit the Neuromuscular Research Laboratory on 6 separate occasions, with 4 of those occasions also requiring a visit to Health services for a blood draw. Procedures (methods): During pre-screening, each participant will complete an informed consent document, a health history questionnaire, and have their stature and body mass assessed. A familiarization session will then be conducted on a separate day where all participants will practice the strength assessment, eccentric isokinetic protocol, and ultrasound assessments. Participants will be assigned to 1 of the 4 treatment groups based on their initial maximal isometric strength values using a matched-participants design. The first experimental session will then begin 2-10 days later, where the participants will perform the repeated eccentric exercise protocol (10 sets of 15 eccentric contractions 210 deg/sec with 3 min of rest between sets) with the non-dominant leg following a 60 min rest period where they will wear the apparel and perform a 5 min warm-up on a cycle ergometer. Follow-up blood draws and strength and ultrasound assessments will be obtained at 24 and 48 hours post-exercise. Each participant will also complete a visual analog scale at baseline, 24, 48, and 72 hours post-exercise to examine perceived muscle soreness.
Interventions
OTHERFar Infrared Fabric
OTHERSpandex
Sponsors
Rhodia, Inc
University of North Carolina, Chapel Hill
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Cohort of Adult Males & Females * Participant is between the ages of 18-35 * Healthy, Recreationally Active (1-5 hours per week) * Participant has provided written and dated informed consent to participate in the study * Participant is apparently healthy and free from disease, as determined by a health history questionnaire * Participant agrees to abstain from smoking, caffeine (4hrs prior), tobacco (24hrs prior), and alcohol (24 hrs) before testing days * Participant agrees to abstain from exercise 24 hours prior to each testing visit and after 72 hours of the induced exercise damage * Participant will refrain from the use of non-steroidal anti-inflammatory drugs (NSAIDs) and protein supplementation 24 hours before the exercise testing protocol, as well as for the 72 hour period following the exercise testing protocol.
Exclusion criteria
* Participant is using, or has used one of the following dietary supplements within 12 weeks prior to enrollment: beta-alanine, creatine, taurine, or any supplemental antioxidants (Acai, pomegranate, beet juice). * Participant is in, or has participated in another clinical trial within 6 weeks prior to enrollment * Participant has a known allergy or sensitivity to test product (determined from health history questionnaire and consent form)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maximal Voluntary Contraction (MVC) | up to 72 hours |
Secondary
| Measure | Time frame |
|---|---|
| Creatine Kinase | baseline, 24 hrs and 48 hrs post |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Compression + Normal Garment Far Infrared Fabric during exercise + Spandex at night
Far Infrared Fabric
Spandex | 20 |
| Normal Garment + Test Garment at Night Spandex during exercise + Far Infrared Fabric at night
Far Infrared Fabric
Spandex | 20 |
| Normal Garment + Normal Garment Spandex during exercise + Spandex at night
Spandex | 20 |
| Test Garment + Test Garment Far Infrared Fabric during exercise + Far Infrared Fabric at night
Far Infrared Fabric | 20 |
| Total | 80 |
Withdrawals & dropouts
| Period | Reason | FG000 | FG001 | FG002 | FG003 |
|---|---|---|---|---|---|
| Overall Study | Lost to Follow-up | 0 | 1 | 1 | 0 |
| Overall Study | muscle soreness | 0 | 0 | 0 | 1 |
| Overall Study | Protocol Violation | 1 | 0 | 0 | 0 |
Baseline characteristics
| Characteristic | Compression + Normal Garment | Normal Garment + Normal Garment | Normal Garment + Test Garment at Night | Test Garment + Test Garment | Total |
|---|---|---|---|---|---|
| Age, Categorical <=18 years | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants |
| Age, Categorical >=65 years | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants |
| Age, Categorical Between 18 and 65 years | 20 Participants | 20 Participants | 20 Participants | 20 Participants | 80 Participants |
| Age, Continuous | 20.5 years STANDARD_DEVIATION 1.4 | 22.1 years STANDARD_DEVIATION 3.2 | 20.9 years STANDARD_DEVIATION 2 | 21.0 years STANDARD_DEVIATION 2.5 | 21 years STANDARD_DEVIATION 2.6 |
| Region of Enrollment United States | 20 participants | 20 participants | 20 participants | 20 participants | 80 participants |
| Sex: Female, Male Female | 12 Participants | 12 Participants | 14 Participants | 12 Participants | 50 Participants |
| Sex: Female, Male Male | 8 Participants | 8 Participants | 6 Participants | 8 Participants | 30 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk | EG002 affected / at risk | EG003 affected / at risk |
|---|---|---|---|---|
| deaths Total, all-cause mortality | 0 / 20 | 0 / 20 | 0 / 20 | 0 / 20 |
| other Total, other adverse events | 0 / 20 | 0 / 20 | 0 / 20 | 0 / 20 |
| serious Total, serious adverse events | 0 / 20 | 0 / 20 | 0 / 20 | 0 / 20 |
Outcome results
Primary
Maximal Voluntary Contraction (MVC)
Time frame: up to 72 hours
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Compression + Normal Garment | Maximal Voluntary Contraction (MVC) | 182.4 Newton-meters | Standard Deviation 45.7 |
| Normal Garment + Test Garment at Night | Maximal Voluntary Contraction (MVC) | 198.7 Newton-meters | Standard Deviation 56.2 |
| Normal Garment + Normal Garment | Maximal Voluntary Contraction (MVC) | 208 Newton-meters | Standard Deviation 70.5 |
| Test Garment + Test Garment | Maximal Voluntary Contraction (MVC) | 186.4 Newton-meters | Standard Deviation 44.1 |
Secondary
Creatine Kinase
Time frame: baseline, 24 hrs and 48 hrs post
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Compression + Normal Garment | Creatine Kinase | Baseline | 140.6 u/L | Standard Error 40.4 |
| Compression + Normal Garment | Creatine Kinase | 48 H post | 225.8 u/L | Standard Error 127.3 |
| Compression + Normal Garment | Creatine Kinase | 24 H post | 277.1 u/L | Standard Error 102.6 |
| Normal Garment + Test Garment at Night | Creatine Kinase | Baseline | 158.2 u/L | Standard Error 41.5 |
| Normal Garment + Test Garment at Night | Creatine Kinase | 48 H post | 355.8 u/L | Standard Error 130.6 |
| Normal Garment + Test Garment at Night | Creatine Kinase | 24 H post | 458.5 u/L | Standard Error 105.2 |
| Normal Garment + Normal Garment | Creatine Kinase | 24 H post | 516.2 u/L | Standard Error 102.6 |
| Normal Garment + Normal Garment | Creatine Kinase | Baseline | 181.2 u/L | Standard Error 40.4 |
| Normal Garment + Normal Garment | Creatine Kinase | 48 H post | 542.9 u/L | Standard Error 127.3 |
| Test Garment + Test Garment | Creatine Kinase | Baseline | 108.2 u/L | Standard Error 41.5 |
| Test Garment + Test Garment | Creatine Kinase | 48 H post | 263.6 u/L | Standard Error 130.6 |
| Test Garment + Test Garment | Creatine Kinase | 24 H post | 332.8 u/L | Standard Error 105.2 |