Determine Immune Cell Types in Subcutaneous Adipose Tissue
Conditions
Keywords
Subcutaneous adipose tissue, Lipectomy
Brief summary
The overall goal of this proposal is to characterize the immune cell profile of subcutaneous abdominal adipose tissue in lean, overweight, obese and lipedema adults, and to evaluate potential associations between different adipose tissue immune cell types and metabolic profile.
Interventions
PROCEDURELiposuction/lipectomy
Subcutaneous adipose tissue will be obtained from liposuction/lipectomy to determine the types of immune cells
Sponsors
Washington University School of Medicine
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Women of all races and ethnicity * Age between 18 and 65 years * Body Mass Index (BMI) ≥ 18.5 kg/m² * Weight stable (+/- 3% during the last 2 months before enrollment) * Women already scheduled for above mentioned procedures
Exclusion criteria
* Diabetes Mellitus * Recent (\<5 years) history of cancer (except in situ ductal breast carcinoma) * Chemotherapy and/or radiation therapy within 4 months before enrollment * Immune system diseases (i.e., autoimmune disorders, acquired immunodeficiency syndrome) * Pregnant or breastfeeding * Take any medication that might affect immune function * Severe organ dysfunction * BMI \<18.5 kg/m² or size of each breast is \>600 grams, if scheduled for bilateral breast reconstruction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determine the types of immune cells and the relative prevalence of each type and sub-type, in subcutaneous adipose tissue of normal weight, overweight, obese and lipedema adults. | intraoperative |
Secondary
| Measure | Time frame |
|---|---|
| Determine the relationships among specific types and subtypes of immune cells, adiposity and cardiometabolic risk. | Baseline |
Countries
United States
Outcome results
None listed