Biomarkers of Early Chronic Obstructive Pulmonary Disease (COPD) in Smokers - Longitudinal Study

Biomarkers of Early Chronic Obstructive Pulmonary Disease (COPD) and Cardiovascular Diseases in Smokers/Ex-Smokers Attending Primary Care - Longitudinal Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02076061

Enrollment

300

Registered

2014-03-03

Start date

2014-02-28

Completion date

2020-04-30

Last updated

2022-08-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Disease, Chronic Obstructive Pulmonary Disease, Lung Cancer

Keywords

COPD, Primary Care, Smoking, Smokers, ex-Smokers, Lung Cancer, Cardiovascular Disease, Proteomics, Biomarkers, Biobank, Disease Staging, Gold Stage

Brief summary

This is a longitudinal observational study to identify and validate protein biomarkers for COPD (chronic obstructive pulmonary diseases) and cardiovascular disease in smokers and ex-smokers attending primary care. Special emphasize is to correlate biomarkers to different phases of COPD, to progression of the disease, and to treatment of the disease. Furthermore, linkage between COPD, cardiovascular disease, and lung cancer will be investigated by identifying protein biomarkers.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

35 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

Diagnosed with COPD Gold stage 0-IV

Exclusion criteria

Patients with inflammatory diseases Patients with cancer Patients using immune system regulating drugs

Design outcomes

Primary

Measure	Time frame
Advanced disease etiology requiring hospitalization.	2 years

Countries

Sweden

Outcome results