The Effect of Ingesting or Rinsing Sucrose and Sucralose on Self-control, Cognitive Performance, and Blood Glucose

The Effects of Ingesting or Rinsing Sucrose and Sucralose Solutions on Self-control, Cognitive Performance, and Blood Glucose Level

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02075333

Enrollment

Registered

2014-03-03

Start date

2014-01-31

Completion date

2014-08-31

Last updated

2016-05-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood Glucose Response, Cognitive Performance, Self-control

Brief summary

The purpose of this study is to examine the effects of ingesting or mouth rinsing a sucrose (carbohydrate) versus a sucralose (carbohydrate-free) drink on self control, cognitive performance, and blood glucose level.

Interventions

DIETARY_SUPPLEMENTIngestion of solution

Participants will ingest the solution

DIETARY_SUPPLEMENTRinising of solution

Participants rinse the solution in the oral cavity

Study design

Allocation

NON_RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

50 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* BMI 18 - 29 kg/m2

Exclusion criteria

* Dementia * Depression * Type 2 diabetes * Phenylketonuria * Intake of medication known to affect glucose metabolism * Fasting blood glucose \> 7.8 mmol/L

Design outcomes

Primary

Measure	Time frame	Description
Capillary blood glucose change from baseline following rinsing or ingesting sucrose or sucralose solutions	- 30, -15, - 5, + 5, + 10, + 20, + 30, + 40 minutes relative to rinsing or ingestion of sucrose or sucralose solutions (each separated by 7 days in crossover manner)	Change from baseline in capillary blood glucose (assessed by lancet fingerprick and YSI blood glucose analyser)

Secondary

Measure	Time frame	Description
Visual verbal learning and memory performance following self-control depletion	+ 35 minutes post ingestion or rinsing of sucrose or sucralose solutions (each separated by 7 days in crossover manner)	Visual verbal learning performance will be assessed by the Visual Verbal Learning Test (Rey, 1964) following a self-control depletion task and ingestion or rinsing of a sucrose or sucralose solution
Attention switching performance following self-control depletion	+ 20 minutes post ingestion or rinsing of sucrose or sucralose solutions (each separated by 7 days in crossover manner)	Attention switching performance will be assessed by a switch task (Rogers and Monsell, 1995) following a self-control depletion task and ingestion or rinsing of a sucrose or sucralose solution
Continuous blood glucose change from baseline following rinsing or ingesting sucrose or sucralose solutions	24 hours preceding and during ingestion or rinsing of sucrose or sucralose solutions (each separated by 7 days in a crossover manner)	A subgroup of 10 participants recruited into the study will be fitted with a continuous glucose monitoring device (CGMS, iPRO) the day preceding each of the test days to measure continuous interstitial blood glucose levels

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026