CT Perfusion Changes in GI Cancer During Adenosine Vasodilation Test

Abdominal Tissue Perfusion Changes in Esophageal and Gastric Cancer During Adenosine Vasodilation Measured With Computed Tomography (CT) Perfusion

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02074124

Enrollment

Registered

2014-02-28

Start date

2012-10-31

Completion date

2013-12-31

Last updated

2014-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophageal Cancer, Gastric Cancer

Brief summary

The aim of this study was to investigate changes in abdominal tissue perfusion during adenosine vasodilation. Our hypotheses were that CT perfusion measurements are altered by changes in the circulatory system mediated by adenosine, and a more differentiated assessment of the circulatory capacity of abdominal tumours could be achieved by sequential rest and adenosine vasodilation CT perfusion measurements.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to No maximum

Healthy volunteers

Inclusion criteria

* Tumour larger than 1.5 cm on diagnostic CT * Normal serum creatinine * Age above 18 * Informed written and oral consent.

Exclusion criteria

* Contrast allergy or contrast induced nephropathy * BMI \> 40 * Asthma or Chronic Obstructive Lung Disease * Heart failure (NYHA III+) * Heart conduction disorder * Atrial fibrillation * 2nd/3rd Heart block * Long QT syndrome * Wolf Parkinson White Syndrome * Moderate / severe aortic stenosis * Haemodynamic contraindications for adenosine, systolic pressure below 90

Design outcomes

Primary

Measure	Time frame
Change in arterial flow during adenosine vasodilation test (CT perfusion parameter)	0 min and 15 min

Secondary

Measure	Time frame	Description
Change in Blood pressure during adenosine vasodilation test	0 min and 15 min	—
Change in Heart rate during adenosine vasodilation test	0 min and 15 min	—
Change in Area under arterial input curve during adenosine vasodilation test	0 min and 15 min	Area Under Curve (AUC) is correlated to cardiac output
Change in Blood volume (CT perfusion parameter) during adenosine vasodilation test	0 min and 15 min	—
Change in Permeability (CT perfusion parameter) during adenosine vasodilation test.	0 min and 15 min	—

Countries

Denmark

Outcome results