Atrial Fibrillation, Coronary Artery Disease
Conditions
Brief summary
Patients with coronary artery disease (CAD) and atrial fibrillation (AF) are at increased risk of stroke and heart attack. Such events are usually caused by increased stickiness of the blood causing a blood clot to block the artery (thrombus) in the heart or the brain. The aim of this study is to assess the stickiness of the blood (global thrombotic status) in patients with CAD and AF at baseline and after clinical stabilisation to see how disease state and clinical treatments affect the stickiness of the blood (thrombotic status). This will be a single centre study. Patients diagnosed with CAD or AF will have a blood sample taken at baseline and after clinical stabilisation. Blood stickiness will be tested with the Global Thrombosis Test. The results will be evaluated to assess the effect of disease process and clinical state on blood stickiness to gain further understanding of this condition and form the basis for future studies aimed at identifying patients who are at high risk of future cardiovascular events, based on increased blood stickiness.
Detailed description
Impaired thrombotic status is associated with adverse cardiovascular events. Patients with coronary artery disease (CAD) and atrial fibrillation (AF) are at increased risk of thrombotic events. It is not known whether thrombotic status differs in these patients, or how thrombotic status alters in response to clinical stabilisation with treatment. The aim of this study is to assess the global thrombotic status (stickiness of the blood) in patients with coronary artery disease and atrial fibrillation at baseline and after clinical stabilisation. This is a small, pilot, hypothesis-generating study. Design Single centre, hypothesis-generating study. Patients diagnosed with coronary disease (n=70) or atrial fibrillation (n=70) recruited from amongst in-patients or out-patients, will have a blood draw at presentation and after clinical stabilisation. Blood will be tested to assess global thrombotic status. The recruitment period is 3 years.
Interventions
DIAGNOSTIC_TESTBlood test
Patients will undergo the tests of thrombosis, before and after stabilisation of their cardiac condition. Cardiac stabilisation will be provided by clinical cardiac teams, outside and independently from the study.
Sponsors
East and North Hertfordshire NHS Trust
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Male and female participants aged 18 years or over. 2. Patients diagnosed with CAD or AF and free of
Exclusion criteria
below. 3. Not actively using tobacco products (due to vasoactive and pro-aggregatory effects of nicotine). 4. The participant is willing and able to understand the Subject Information Sheet and provide informed consent. 5. The participant must agree to comply with the drawing of blood samples for the assessments.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The occlusion and lysis time. | 1-3 months | The occlusion and lysis timet. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| no secondary outcome measures to be identified | no secondary outcome measures to be identified | no secondary outcome measures to be identified |
Other
| Measure | Time frame | Description |
|---|---|---|
| no other outcome measures to be identified | no other outcome measures to be identified | no other outcome measures to be identified |
Countries
United Kingdom
Outcome results
None listed