Frailty, Sarcopenia
Conditions
Brief summary
Sarcopenia related mobility dysfunction was a preventable presentation in transitional variation of frailty. However, the definition, associated risk factors, clinical course and outcome of sarcopenia in Taiwanese older adults are still under-clarified and need for further study.
Interventions
None listed
Sponsors
National Health Research Institutes, Taiwan
National Taiwan University
National Taiwan University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* functional decline in recent one year * cognitive impairment * depressive symptom * mobility impairment * fall in recent one year * eating or feeding problems * weight loss * co-morbid conditions≧5 * tracking by different physician ≧3 in recent half year * poly-pharmacy≧8 in recent 3 months * hospitalization ≧1 in recent one year * emergency visits≧2 in recent one year * aged ≧ 80.
Exclusion criteria
* non-ambulatory (bed-ridden) patients * long-term residents at nursing homes * patients with a life expectancy shorter than six months * impairment in vision, hearing, or communicative ability, making convenience of clinical evaluation during the study period impossible.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Domestic operation tool of sarcopenia for older adults | Baseline | Young health adults are recruited for measurement of body composition using bio impedance analysis in order to establish the norm of skeletal muscle index |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in body composition during aging | up to 2 years | Using anthropometric measurements, and bio impedance analysis, the change in body composition are measured in the recruited older adults |
Other
| Measure | Time frame | Description |
|---|---|---|
| Compare metabolomics profiles in sarcopenic older adults and non-sarcopenic older adults | up to 2 years | Using the blood specimen, the metabolomics platform are set up to explore the new bio markers of sarcopenia in older adults |
| The prognosis of sarcopenia in the older adults | up to 2 years | The adverse health outcomes, including hospitalization, emergency visits, or fall events, are recorded every 3 months in order to examine the prognosis of sarcopenia in the elderly |
Countries
Taiwan
Outcome results
None listed