Estrogen and the Outer Eye in Women During Fertility Treatment

The Influence of the Hormonal Fertility Treatment of Women, on the Eye Surface and the Eye Dryness

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02072122

Enrollment

Registered

2014-02-26

Start date

2014-03-31

Completion date

2014-07-31

Last updated

2014-02-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dry Eye Syndromes

Keywords

dry eye, fertility treatment, Meibomian gland dysfunction, supra physiologic estrogen level

Brief summary

The purpose of this study is to determine the relation between estrogen and progesterone levels, and between dryness of the eyes, in women during their fertile years.

Detailed description

Women during their fertility treatments will be submitted to the research. The research will include 3 meetings with a doctor from the ophthalmology department. Each meeting will be individual for each participant of the research. The meetings will take place during the day of regular appointment of the participant to the fertility clinic. Meeting #1: During first visit to the fertility clinic for the stimulation process. During this day will be done: 1.Submission of the patient to the research and signing on letter of agreement 2.Blood tests for estrogen, progesterone, luteinizing hormone (LH) 3.Eye examination: 3a. Filling of Schein Questionnaire 3b. Examination of the external eye: 1.microscope, 2.Schirmer test (paper strips inserted into the eye for several minutes to measure the production of tears), 3. tear break up time test (checking the eye with the fluorescein light after painting the eye with fluorescein dye) 3c. Checking the Intra Ocular Pressure with Tonometer Meeting #2: During visit to the fertility clinic for the egg collection (about 10 days after meeting #1) During this day will be done: 1.Blood tests for estrogen, progesterone, luteinizing hormone (LH) 2.Eye examination: 2a. Filling of Schein Questionnaire 2b. Examination of the external eye: 1.microscope, 2.Schirmer test (paper strips inserted into the eye for several minutes to measure the production of tears), 3. tear break up time test (checking the eye with the fluorescein light after painting the eye with fluorescein dye) 2c. Checking the Intra Ocular Pressure with Tonometer Meeting #3: During visit to the fertility clinic for the pregnancy test (about 14 days after meeting #2) During this day will be done: 1. Blood tests for estrogen, progesterone, luteinizing hormone (LH) 2. Eye examination: 2a. Filling of Schein Questionnaire 2b. Examination of the external eye: 1.microscope, 2.Schirmer test (paper strips inserted into the eye for several minutes to measure the production of tears), 3. tear break up time test (checking the eye with the fluorescein light after painting the eye with fluorescein dye) 2c. Checking the Intra Ocular Pressure with Tonometer Collection and summary of all the data End of the research

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 37 Years

Healthy volunteers

Inclusion criteria

* women during fertility treatment * without any known eye diseases * no current or past history of treatment against dry eye

Exclusion criteria

* known eye disease * current or past history of treatment against dry eye

Design outcomes

Primary

Measure	Time frame
Evidence of clinically definite dry eye confirmed by Schirmer test and tear break up time test	24 days

Secondary

Measure	Time frame
Evidence of clinically definite dry eye confirmed by Schirmer test and tear break up time test during each on of the meetings #1,#2 (day 0, day 10)	0 days, 10 days

Outcome results