A Retrospective Study of the Relationship Between White Matter Hyperintensities(WMHs) Within the Cholinergic Pathways and the Cognition of PD Patients After Bilateral STN DBS

Cholinergic Pathways Hyperintensities Scale Could Not Predict the Change of Cognitive Status of Parkinson's Disease Patients After Bilateral STN DBS.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02071693

Enrollment

Registered

2014-02-26

Start date

2013-12-31

Completion date

2014-03-31

Last updated

2014-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's Disease

Keywords

subthalamic nucleus, deep brain stimulation, cognition, white matter hyperintensities

Brief summary

To retrospectively investigate the relationship between the Cholinergic Pathways Hyperintensities Scale (CHIPS) score and the change of cognitive status of Parkinson's disease (PD) patients after bilateral subthalamic nucleus deep brain stimulation (STN DBS).

Detailed description

In this observational study, we will retrospectively analyze 38 PD patients who received bilateral STN DBS in the First Affiliated Hospital of Sun Yat-sen University during the year of 2008-2012. All patients will be evaluated by Unified Parkinson's Disease Rating Scale part III(UPDRSIII) before and after operation. Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment(MoCA) in the on medication condition pre-operation and on stimulation on medication condition post-operation. The follow-up time points are one week pre-operation and 6, 12, 24 months post-operation. Before operation, white matter hyperintensities（WMHs）in the cholinergic pathways will be determined on a 3.0 Tesla MRI, using the visual rating scale of Cholinergic Pathways Hyperintensities Scale (CHIPS). A correlation analysis will be conducted to investigate the relationship between CHIPS score and the change of cognitive status of PD patients after bilateral STN DBS retrospectively.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of Parkinson's disease according to United Kingdom Parkinson's Disease Brain Bank Criteria * Experience bilateral STN DBS surgery in the First Affiliated Hospital, Sun Yat-sen University, China. * Preoperative 3.0 Tesla MRI scanning.

Exclusion criteria

* Loss to follow-up * Participation in other clinical trials

Design outcomes

Primary

Measure	Time frame
Change of MoCA score during follow-up and its relationship with preoperative CHIPS score	Pre-operation and 6, 12, 24 months post-operation
Change of MMSE score during follow-up and its relationship with preoperative CHIPS score	Pre-operation and 6, 12, 24 months post-operation

Secondary

Measure	Time frame
Change of UPDRS III score during follow-up and its relationship with preoperative CHIPS score	Pre-operation and 6, 12, 24 months post-operation

Countries

China

Outcome results