Association of Periostin Levels and Chronic Sinusitis

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02071667

Enrollment

Registered

2014-02-26

Start date

2014-09-30

Completion date

2016-10-31

Last updated

2017-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nasal Polyps, Sinusitis

Keywords

Chronic sinusitis, Nasal Polyps

Brief summary

The purpose of this study is to see if a protein in blood, called periostin, can determine if patients have chronic sinusitis. This protein is in everyone's body, but the level of the protein may indicate certain conditions such as chronic sinusitis. The investigators are interested in testing levels of periostin to see if they are higher or lower than patients without chronic sinusitis, just as periostin is higher in patients with asthma. All patients enrolled in this study will have chronic sinusitis without asthma.

Interventions

OTHERBlood draw

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Patients with sinus disease which requires surgical intervention * Ability to understand and give informed consent

Exclusion criteria

* Previous diagnosis of asthma * Positive methacholine challenge at screening * Diagnosis of cystic fibrosis * Concomitant use of systemic corticosteroids (except for those prescribed as part of standard pre-surgical treatment)

Design outcomes

Primary

Measure	Time frame	Description
Difference in circulating serum periostin levels pre and post sinus surgery	10-15 weeks	Serum collected prior to and following sinus surgery will be analyzed for concentrations of the protein periostin.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026