Actual Impaired Fluid Volume, Mechanical Ventilation Complication
Conditions
Brief summary
The investigators hypothesize that large doses of fluids used during intraoperative could affect lung parenchyma structure and, consequently, gas exchange and respiratory mechanics. The purpose of this study is to evaluate fluids effects on oxygenation, respiratory mechanics, by using two different solutions: crystalloid or colloid.
Detailed description
Inclusion Criteria: * patients undergoing elective abdominal, thoracic, vascular surgery * minimum age 18 years * informed consent Exclusion Criteria: * patients with severe cardiomyopathy or severe heart failure * history of coagulation disorders * patients with severe cardiovascular or respiratory disorders * renal insufficiency Respiratory mechanic parameters (i.e., inspiratory peak pressure, plateau pressure, total airway resistance, and static compliance) are obtained .Blood samples are drawn simultaneously from the arterial catheters for gas analysis. Data were collected after induction of anesthesia (T0) after 1 h (T1), 2 h (T2), 3 h (T3) and at the end of surgery. Primary outcome: evaluate the fluids effects on oxygenation, respiratory mechanics Secondary outcome: Incidence of surgery related complications
Interventions
DRUGGroup Colloid
Group Colloid: cristalloid 1:2 (gelofusine: ringer lactate)
DRUGCristalloid administration
Only Ringer Lactate administration
Sponsors
Università degli Studi di Ferrara
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* patients undergoing elective abdominal, thoracic, vascular surgery * minimum age 18 years * informed consent
Exclusion criteria
* patients with severe cardiomyopathy or severe heart failure * history of coagulation disorders * patients with severe cardiovascular or respiratory disorders * renal insufficiency * severe liver diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| effects on oxygenation, respiratory mechanics | every 30 minutes till the end of surgery | Lung compliance (l/cmH20), Airaway resistance (cmH2O/L/sec) and PaO2 will be measured |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of respiratory complications | 28 days | Complications like acute respiratory failure, pneumonia and ARDS will be recorded |
Countries
Italy
Contacts
Primary ContactSavino Spadaro, researcher
Outcome results
None listed