Non ST Segment Elevation Myocardial Infarction, Post MI, Stable Angina, Unstable Angina
Conditions
Keywords
Alpha-tocopherol, Vitamin E, Contrast-Induced Acute Kidney Injury, Coronary angiography
Brief summary
The purpose of this study is to evaluate the effect of vitamin E on preventing from incidence of contrast induced acute kidney injury (CI-AKI) in the patients who undergone coronary angiography.
Interventions
DRUGVitamin E
Sponsors
Urmia University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. All patients whon have either stable coronary artery disease (CAD) or recent acute coronary disease (ACS) and are scheduled for coronary angiography. 2. Patients who have eGFR ≤60 ml/min/1.73 m2
Exclusion criteria
1. Allergy to contrast media 2. Cardiogenic shock 3. Pulmonary edema 4. Overt cardiac failure or left ventricular ejection fraction ≤ 30% 5. Acute kidney injury 6. The history of receiving contrast media for any medical diagnostic or therapeutic procedures during previous 5 days 7. The history of dialysis 8. Being pregnant 9. Having recent acute myocardial infarction 10. Taking antioxidants and nephrotoxic drugs including NSAID and ACE-I on previous 2 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The development of CI-AKI in group receiving vitamin E compared with placebo | Within 72 hours after coronary angiography |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the serum level of Cr and the amount of eGFR | Within 72 hours |
Countries
Iran
Outcome results
None listed